Rabbit polyclonal ARHGEF3 antibody (A8490)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ARHGEF3 antibody (A8490)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ARHGEF3 antibody.

Alternative names:

Check alternative names for the antibody

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GEF3 antibody, STA3 antibody, XPLN antibody
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SCBT cat No:

Name

Rabbit polyclonal ARHGEF3 antibody

Catalogue No.

A8490

Reactivity

Human

Immunogen

Recombinant protein of human ARHGEF3

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 60kDa/Observed: Refer to figures

Formulation

ARHGEF3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ARHGEF3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GEF3 antibody, STA3 antibody, XPLN antibody

Database links

Human UniProt/Swiss-Prot:Q9NR81

Protein names

GEF3, STA3, XPLN

Protein function

Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.

Protein tissue specificity

Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney.

Protein sequence and domain

Contains 1 DH (DBL-homology) domain.; Contains 1 PH domain.

Protein cellular localization

Cytoplasm .

Background

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Note

AntibodyPlus can customize ARHGEF3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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