Rabbit polyclonal ASGR1 antibody (A6871)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ASGR1 antibody (A6871)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:1000 – 1:4000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

HL-1 antibody, ASGPR antibody, ASGPR1 antibody, CLEC4H1 antibody
ASGP-R 1 antibody|ASGPR 1 antibody|ASGPR antibody|ASGPR1 antibody|Asgr1 antibody|ASGR1_HUMAN antibody|Asialoglycoprotein receptor 1 antibody|C type lectin domain family 4 member H1 antibody|C-type lectin domain family 4 member H1 antibody|CLEC4H1 antibody|Hepatic lectin H1 antibody|HL-1 antibody|Anti-Asialoglycoprotein Receptor 1 antibody (ab49355)

SCBT cat No: sc-13469|

Name

Rabbit polyclonal ASGR1 antibody

Catalogue No.

A6871

Reactivity

Human

Immunogen

Recombinant protein of human ASGR1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:1000 – 1:4000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 33kDa/Observed: Refer to figures

Formulation

ASGR1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ASGR1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HL-1 antibody, ASGPR antibody, ASGPR1 antibody, CLEC4H1 antibody

Database links

Human UniProt/Swiss-Prot:P07306

Protein names

HL-1, ASGPR, ASGPR1, CLEC4H1

Protein function

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Protein tissue specificity

Expressed exclusively in hepatic parenchymal cells.

Protein sequence and domain

Contains 1 C-type lectin domain.

Protein post-translational modifications

Phosphorylated on a cytoplasmic Ser residue.

Protein cellular localization

Isoform H1a: Membrane; Single-pass type II membrane protein.; Isoform H1b: Secreted .

Background

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Note

AntibodyPlus can customize ASGR1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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