Rabbit polyclonal ATF1 antibody (A5791)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ATF1 antibody (A5791)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ATF1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

TREB36 antibody, EWS-ATF1 antibody, FUS/ATF-1 antibody
Activating transcription factor 1 antibody|ATF 1 antibody|atf1 antibody|ATF1 EWS fusion gene antibody|ATF1 FUS fusion gene antibody|ATF1_HUMAN antibody|cAMP dependent transcription factor 1 antibody|cAMP-dependent transcription factor ATF-1 antibody|Cyclic AMP dependent transcription factor ATF 1 antibody|Cyclic AMP dependent transcription factor ATF1 antibody|Cyclic AMP-dependent transcription factor ATF-1 antibody|EWS AFT1 antibody|FUS ATF 1 antibody|FUS/ATF 1 antibody|Protein TREB36 antibody|RNA binding protein activating transcription factor 1 fusion protein antibody|TREB 36 antibody|TREB36 antibody|TREB36 protein antibody|Phospho anti-ATF1 (S63) antibody [EP1591(2)Y] (ab76085)

SCBT cat No: sc-270|sc-53172|sc-243|sc-241|sc-365525|sc-187|sc-242|

Name

Rabbit polyclonal ATF1 antibody

Catalogue No.

A5791

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ATF1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 29kDa/Observed: Refer to Figures

Formulation

ATF1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ATF1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

TREB36 antibody, EWS-ATF1 antibody, FUS/ATF-1 antibody

Database links

Human UniProt/Swiss-Prot:P18846

Protein names

TREB36, EWS-ATF1, FUS/ATF-1

Protein function

This protein binds the cAMP response element (CRE) (consensus: 5′-GTGACGT[AC][AG]-3′), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.

Protein sequence and domain

Belongs to the bZIP family. ATF subfamily.; Contains 1 bZIP (basic-leucine zipper) domain.; Contains 1 KID (kinase-inducible) domain.

Protein post-translational modifications

Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.

Protein cellular localization

Nucleus.

Background

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.

Research area

All research areas>Transcription Regulators>ATF
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize ATF1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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