Rabbit polyclonal ATG4A antibody (A2598)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ATG4A antibody (A2598)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IP 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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APG4A antibody, AUTL2 antibody
AI627006 antibody|AV169859 antibody|Cysteine protease ATG4A antibody|hAPG4A antibody|MGC107179 antibody|Anti-ATG4A antibody [EPR4122] (ab108322)

SCBT cat No: sc-131432|

Name

Rabbit polyclonal ATG4A antibody

Catalogue No.

A2598

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ATG4A

Host

Rabbit

Applications

WB, IHC, IP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IP 1:20 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 45kDa/Observed: Refer to Figures

Formulation

ATG4A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ATG4A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

APG4A antibody, AUTL2 antibody

Database links

Human UniProt/Swiss-Prot:Q8WYN0

Protein names

APG4A, AUTL2

Protein function

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Protein tissue specificity

Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver.

Protein sequence and domain

Belongs to the peptidase C54 family.

Protein cellular localization

Cytoplasm .

Background

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.

Research area

All research areas>Synthesis and Degradation>Atg
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize ATG4A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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