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Rabbit polyclonal ATG4B antibody (A2837)
$69.00–$259.00
Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.
Rabbit polyclonal ATG4B antibody (A2837)
Supplier: ABclonal Inc.
Recommended applications: WB
Recommended dilution:
WB 1:500 – 1:2000
Recommended protocols: check protocols
Image descriptions:
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Alternative names:
Check alternative names for the antibody
ExpandAPG4B antibody, AUTL1 antibody
APG4 autophagy 4 homolog B antibody|Cysteine protease ATG4B antibody|hAPG4B antibody|MGC1353 antibody|Anti-ATG4B antibody [EPR6436(2)] (ab154843)
SCBT cat No: sc-367838|sc-83371|sc-130968|
Name | Rabbit polyclonal ATG4B antibody |
---|---|
Catalogue No. | A2837 |
Reactivity | Human |
Immunogen | Recombinant protein of human ATG4B |
Host | Rabbit |
Applications | WB |
Recommended dilution | WB 1:500 – 1:2000 |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Molecular weight | Predicted: 44kDa/Observed: Refer to figures |
Formulation | ATG4B antibody was tube-contained. |
Purification | ATG4B antibody was purified using affinity purification. |
Storage | Store at -20 Celsius degree. Avoid freeze / thaw cycles. |
Alternative antibody names | APG4B antibody, AUTL1 antibody |
Database links | Human UniProt/Swiss-Prot:Q9Y4P1 |
Protein names | APG4B, AUTL1 |
Protein function | Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. |
Protein tissue specificity | Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. |
Protein sequence and domain | Belongs to the peptidase C54 family. |
Protein cellular localization | Cytoplasm . |
Background | Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
Research area | All research areas>Synthesis and Degradation>Atg |
Note | AntibodyPlus can customize ATG4B antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation. |
Product type | Primary antibody |
Supplier | ABclonal Inc. |
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