Rabbit polyclonal ATG4C antibody (A7396)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ATG4C antibody (A7396)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ATG4C antibody.

Alternative names:

Check alternative names for the antibody

Expand

APG4C antibody, AUTL1 antibody, AUTL3 antibody, APG4-C antibody
APG4 autophagy 4 homolog C (S. cerevisiae) antibody|Cysteine protease ATG4C antibody|EC 3.4.22 antibody|FLJ14867 antibody|OTTHUMP00000010715 antibody|Anti-ATG4C antibody – C-terminal (ab191705)

SCBT cat No: sc-163708|

Name

Rabbit polyclonal ATG4C antibody

Catalogue No.

A7396

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ATG4C

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 52kDa/Observed: Refer to figures

Formulation

ATG4C antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ATG4C antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

APG4C antibody, AUTL1 antibody, AUTL3 antibody, APG4-C antibody

Database links

Human UniProt/Swiss-Prot:Q96DT6

Protein names

APG4C, AUTL1, AUTL3, APG4-C

Protein function

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Protein tissue specificity

Highly expressed in skeletal muscle, heart, liver and testis.

Protein sequence and domain

Belongs to the peptidase C54 family.

Protein cellular localization

Cytoplasm .

Background

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized.

Research area

All research areas>Synthesis and Degradation>Atg
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize ATG4C antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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