Rabbit polyclonal ATP7B antibody (A5676)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ATP7B antibody (A5676)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ATP7B antibody.

Alternative names:

Check alternative names for the antibody

Expand

WD antibody, PWD antibody, WC1 antibody, WND antibody
ATP7B antibody|ATP7B_HUMAN antibody|ATPase, Cu(2+) transporting, beta polypeptide antibody|ATPase, Cu++ transporting, beta polypeptide antibody|Copper pump 2 antibody|Copper transporting ATPase 2 antibody|PWD antibody|Toxic milk antibody|tx antibody|WC1 antibody|WD antibody|Wilson disease associated protein antibody|Wilson disease-associated protein antibody|WND antibody|WND/140 kDa antibody|Anti-ATP7b antibody [EPR6794] (ab124973)

SCBT cat No: sc-373964|sc-33826|sc-32446|sc-32445|

Name

Rabbit polyclonal ATP7B antibody

Catalogue No.

A5676

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ATP7B

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 157kDa/Observed: Refer to Figures

Formulation

ATP7B antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ATP7B antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

WD antibody, PWD antibody, WC1 antibody, WND antibody

Database links

Human UniProt/Swiss-Prot:P35670

Protein names

WD, PWD, WC1, WND

Protein function

Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.

Protein tissue specificity

Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues.

Protein sequence and domain

Each HMA domain can bind a copper ion, they are tightly packed and closely interact with each other. Wild-type ATP7B can usually be loaded with an average 5.5 copper atoms per molecule.Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.; Contains 6 HMA domains.

Protein post-translational modifications

Isoform 1 may be proteolytically cleaved at the N-terminus to produce the WND/140 kDa form.

Protein cellular localization

Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Note: Predominantly found in the trans-Golgi network (TGN). Not redistributed to the plasma membrane in response to elevated copper levels.; Isoform 1: Golgi apparatus membrane ; Multi-pass membrane protein .; Isoform 2: Cytoplasm .; WND/140 kDa: Mitochondrion .

Background

This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).

Note

AntibodyPlus can customize ATP7B antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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