Rabbit polyclonal ATXN3 antibody (A1243)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ATXN3 antibody (A1243)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ATXN3 antibody.

Alternative names:

Check alternative names for the antibody

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ATXN3 antibody,AT3 antibody,ATX3 antibody,JOS antibody,MJD antibody,MJD1 antibody,SCA3 antibody
AT3 antibody|Ataxin 3 antibody|ataxin 3 variant h antibody|ataxin 3 variant m antibody|ataxin 3 variant ref antibody|Ataxin-3 antibody|ATX3 antibody|ATX3_HUMAN antibody|ATXN3 antibody|EC 3.4.22. antibody|JOS antibody|Josephin antibody|Machado Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) antibody|Machado Joseph disease antibody|Machado Joseph disease protein 1 antibody|Machado-Joseph disease protein 1 antibody|Machado-Joseph disease protein 1 homolog antibody|MJD antibody|MJD gene antibody|MJD1 antibody|Olivopontocerebellar ataxia 3 antibody|OTTHUMP00000221583 antibody|OTTHUMP00000221585 antibody|OTTHUMP00000221586 antibody|OTTHUMP00000221587 antibody|OTTHUMP00000231995 antibody|OTTHUMP00000231997 antibody|Rsca3 antibody|SCA3 antibody|SCA3 gene antibody|Spinocerebellar ataxia type 3 protein antibody|Anti-Ataxin 3 antibody (ab175265)

SCBT cat No: sc-398114|sc-393193|sc-367680|

Name

Rabbit polyclonal ATXN3 antibody

Catalogue No.

A1243

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ATXN3

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 43kDa/Observed: Refer to Figures

Formulation

ATXN3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ATXN3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ATXN3 antibody,AT3 antibody,ATX3 antibody,JOS antibody,MJD antibody,MJD1 antibody,SCA3 antibody

Database links

Human UniProt/Swiss-Prot:P54252

Protein names

ATXN3,AT3,ATX3,JOS,MJD,MJD1,SCA3

Protein function

Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. In response to misfolded substrate ubiquitination, mediates deubiquitination of monoubiquitinated STUB1/CHIP. Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

The UIM domains bind ubiquitin and interact with various E3 ubiquitin-protein ligase, such as STUB1/CHIP. They are essential to limit the length of ubiquitin chains (By similarity).Contains 1 Josephin domain.; Contains 3 UIM (ubiquitin-interacting motif) domains.

Protein post-translational modifications

Monoubiquitinated N-terminally by UBE2W, possibly leading to activate the deubiquitinating enzyme activity.

Protein cellular localization

Nucleus matrix . Note: Predominantly nuclear, but not exclusively, inner nuclear matrix.

Background

Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2009]

Research area

All research areas>Signaling Intermediates>Ataxin
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize ATXN3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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