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Rabbit polyclonal AUH antibody (A7424)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal AUH antibody.
Check alternative names for the antibodyExpand
3 methylglutaconyl CoA hydratase antibody|AU binding protein/enoyl CoA hydratase antibody|AU RNA binding protein/enoyl CoA hydratase antibody|AU RNA binding protein/enoyl Coenzyme A hydratase antibody|AU specific RNA binding antibody|AU specific RNA binding enoyl CoA hydratase antibody|Methylglutaconyl CoA hydratase antibody|Methylglutaconyl CoA hydratase mitochondrial antibody|MGA Type I antibody|Anti-AUH antibody [EPR11087(B)] (ab155980)
SCBT cat No: sc-82521|
Rabbit polyclonal AUH antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human AUH
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 36kDa/Observed: Refer to figures
AUH antibody was tube-contained.
AUH antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5′-AUUUA-3′ motifs.
|Protein sequence and domain|| |
Belongs to the enoyl-CoA hydratase/isomerase family.
|Protein cellular localization|| |
The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3′ UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form.
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|Product type|| |
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