Rabbit polyclonal AUH antibody (A7424)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal AUH antibody (A7424)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

3 methylglutaconyl CoA hydratase antibody|AU binding protein/enoyl CoA hydratase antibody|AU RNA binding protein/enoyl CoA hydratase antibody|AU RNA binding protein/enoyl Coenzyme A hydratase antibody|AU specific RNA binding antibody|AU specific RNA binding enoyl CoA hydratase antibody|Methylglutaconyl CoA hydratase antibody|Methylglutaconyl CoA hydratase mitochondrial antibody|MGA Type I antibody|Anti-AUH antibody [EPR11087(B)] (ab155980)

SCBT cat No: sc-82521|

Name

Rabbit polyclonal AUH antibody

Catalogue No.

A7424

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human AUH

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 36kDa/Observed: Refer to figures

Formulation

AUH antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

AUH antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:Q13825

Protein function

Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5′-AUUUA-3′ motifs.

Protein sequence and domain

Belongs to the enoyl-CoA hydratase/isomerase family.

Protein cellular localization

Mitochondrion .

Background

The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3′ UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form.

Note

AntibodyPlus can customize AUH antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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