Rabbit polyclonal B2M antibody (A1562)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal B2M antibody (A1562)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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beta-2-microglobulin antibody, B2M antibody
B2M antibody|B2MG_HUMAN antibody|Beta 2 microglobin antibody|Beta 2 microglobulin antibody|Beta 2 microglobulin precursor antibody|Beta chain of mhc class 1 proteins antibody|Beta chain of MHC class I molecules antibody|Beta-2-microglobulin form pI 5.3 antibody|CDABP0092 antibody|Hdcma22p antibody|Anti-beta 2 Microglobulin antibody [EP2978Y] (ab75853)

SCBT cat No: sc-8361|

Name

Rabbit polyclonal B2M antibody

Catalogue No.

A1562

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human B2M

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 14kDa/Observed: Refer to Figures

Formulation

B2M antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

B2M antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

beta-2-microglobulin antibody, B2M antibody

Database links

Human UniProt/Swiss-Prot:P61769

Protein names

beta-2-microglobulin, B2M

Protein function

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Protein sequence and domain

Belongs to the beta-2-microglobulin family.; Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Protein post-translational modifications

Glycation of Ile-21 is observed in long-term hemodialysis patients.

Protein cellular localization

Secreted . Note: Detected in serum and urine.

Background

beta2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a ternary membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system (1,2). As an integral component of the MHC class I complex, beta2-microglobulin plays a critically important role in immune system function (3). It has important relevance to cancer biology research; for example, research studies have shown that nearly one-third of diffuse large B cell lymphomas contain mutations that inactivate beta2-microglobulin gene function, thereby allowing tumor cells to escape immune detection (4). In additon, beta2-microglobulin has been identified as an amyloid preprotein with collagen-binding affinity (5); its accumulation in osteoarthritic lesions of long-term dialysis patients is reportedly a contributing factor to the condition known as amyloid osteoarthropathy (6).

Note

AntibodyPlus can customize B2M antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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