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Rabbit polyclonal B4GALT1 antibody (A8546)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal B4GALT1 antibody.
Check alternative names for the antibodyExpand
384.Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase antibody|4-galactosyltransferase 1 antibody|4-GalTase 1 antibody|b4Gal-T1 antibody|B4galt1 antibody|B4GT1_HUMAN antibody|Beta-1 antibody|Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase antibody|Beta4Gal-T1 antibody|CDG2D antibody|GGTB2 antibody|GT1 antibody|GTB antibody|Lactose synthase A protein antibody|N-acetyllactosamine synthase antibody|Nal synthase antibody|Processed beta-1 antibody|UDP-Gal:beta-GlcNAc beta-1 antibody|UDP-galactose:beta-N-acetylglucosamine beta-1 antibody|Anti-B4GALT1 antibody (ab121326)
SCBT cat No: sc-515551|sc-22277|sc-17299|sc-22279|
Rabbit polyclonal B4GALT1 antibody
|Catalogue No.|| |
Recombinant protein of human B4GALT1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 44kDa/Observed: Refer to figures
B4GALT1 antibody was tube-contained.
B4GALT1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.; The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.
|Protein tissue specificity|| |
Ubiquitously expressed, but at very low levels in fetal and adult brain.
|Protein sequence and domain|| |
Belongs to the glycosyltransferase 7 family.
|Protein post-translational modifications|| |
The soluble form derives from the membrane forms by proteolytic processing.
|Protein cellular localization|| |
Isoform Long: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein. Cell membrane ; Single-pass type II membrane protein. Cell surface . Cell projection, filopodium . Note: Found in trans cisternae of Golgi but is mainly localized at the plasma membrane . B4GALT1 cell surface expression is regulated by UBE2Q1 (By similarity).; Isoform Short: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein. Note: Found in trans cisternae of Golgi.; Processed beta-1,4-galactosyltransferase 1: Secreted . Note: Soluble form found in body fluids.
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. [provided by RefSeq, Jul 2008]
AntibodyPlus can customize B4GALT1 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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