Rabbit polyclonal B4GALT1 antibody (A8546)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal B4GALT1 antibody (A8546)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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384.Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase antibody|4-galactosyltransferase 1 antibody|4-GalTase 1 antibody|b4Gal-T1 antibody|B4galt1 antibody|B4GT1_HUMAN antibody|Beta-1 antibody|Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase antibody|Beta4Gal-T1 antibody|CDG2D antibody|GGTB2 antibody|GT1 antibody|GTB antibody|Lactose synthase A protein antibody|N-acetyllactosamine synthase antibody|Nal synthase antibody|Processed beta-1 antibody|UDP-Gal:beta-GlcNAc beta-1 antibody|UDP-galactose:beta-N-acetylglucosamine beta-1 antibody|Anti-B4GALT1 antibody (ab121326)

SCBT cat No: sc-515551|sc-22277|sc-17299|sc-22279|

Name

Rabbit polyclonal B4GALT1 antibody

Catalogue No.

A8546

Reactivity

Human

Immunogen

Recombinant protein of human B4GALT1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 44kDa/Observed: Refer to figures

Formulation

B4GALT1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

B4GALT1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:P15291

Protein function

The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.; The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.

Protein tissue specificity

Ubiquitously expressed, but at very low levels in fetal and adult brain.

Protein sequence and domain

Belongs to the glycosyltransferase 7 family.

Protein post-translational modifications

The soluble form derives from the membrane forms by proteolytic processing.

Protein cellular localization

Isoform Long: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein. Cell membrane ; Single-pass type II membrane protein. Cell surface . Cell projection, filopodium . Note: Found in trans cisternae of Golgi but is mainly localized at the plasma membrane . B4GALT1 cell surface expression is regulated by UBE2Q1 (By similarity).; Isoform Short: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein. Note: Found in trans cisternae of Golgi.; Processed beta-1,4-galactosyltransferase 1: Secreted . Note: Soluble form found in body fluids.

Background

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. [provided by RefSeq, Jul 2008]

Research area

All research areas>Signaling Intermediates>Galactosyltransferases
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize B4GALT1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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