Rabbit polyclonal BACE1 antibody (A5266)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal BACE1 antibody (A5266)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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ASP2 antibody, BACE antibody, HSPC104 antibody
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SCBT cat No:

Name

Rabbit polyclonal BACE1 antibody

Catalogue No.

A5266

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human BACE1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 70kDa/Observed: Refer to Figures

Formulation

BACE1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

BACE1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ASP2 antibody, BACE antibody, HSPC104 antibody

Database links

Human UniProt/Swiss-Prot:P56817

Protein names

ASP2, BACE, HSPC104

Protein function

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

Protein tissue specificity

Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.

Protein sequence and domain

The transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP.Belongs to the peptidase A1 family.; Contains 1 peptidase A1 domain.

Protein post-translational modifications

N-Glycosylated.; Acetylated in the endoplasmic reticulum at Lys-126, Lys-275, Lys-279, Lys-285, Lys-299, Lys-300 and Lys-307. Acetylation by NAT8 and NAT8B is transient and deacetylation probably occurs in the Golgi. Acetylation regulates the maturation, the transport to the plasma membrane, the stability and the expression of the protein.; Palmitoylation mediates lipid raft localization.

Protein cellular localization

Membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network . Endoplasmic reticulum. Endosome . Cell surface. Cytoplasmic vesicle membrane. Membrane raft . Note: Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.

Background

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer’s disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Research area

All research areas>Neurobiology>BACE
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize BACE1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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