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Rabbit polyclonal BAF60a antibody (A9950)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal BAF60a antibody.
Check alternative names for the antibodyExpand
60 kDa BRG-1/Brm-associated factor subunit A antibody|Swp73 like protein antibody|Anti-SMARCD1 antibody (ab83208)
SCBT cat No: sc-135843|sc-514400|sc-82778|
Rabbit polyclonal BAF60a antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human BAF60a
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 123kDa/Observed: Refer to figures
BAF60a antibody was tube-contained.
BAF60a antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Involved in chromatin remodeling. Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
|Protein tissue specificity|| |
|Protein sequence and domain|| |
Belongs to the SMARCD family.; Contains 1 SWIB domain.
|Protein cellular localization|| |
AntibodyPlus can customize BAF60a antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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