Rabbit polyclonal BAG6 antibody (A2010)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal BAG6 antibody (A2010)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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G3 antibody, BAT3 antibody, BAG-6 antibody, D6S52E antibody
2410045D21Rik antibody|AA408914 antibody|BAG 6 antibody|BAG family molecular chaperone regulator 6 antibody|BAG-6 antibody|BAG6 antibody|BAG6_HUMAN antibody|BAT 3 antibody|BCL2-associated athanogene 6 antibody|D17H6S52E antibody|D6S52E antibody|G3 antibody|HLA B associated transcript 3 antibody|HLA-B associated transcript 3 antibody|HLA-B associated transcript-3 antibody|HLA-B-associated transcript 3 antibody|large proline rich protein BAG6 antibody|Large proline rich protein BAT3 antibody|Large proline-rich protein BAG6 antibody|large proline-rich protein BAT3 antibody|Protein G3 antibody|Protein Scythe antibody|Scythe antibody|Scythe, homolog of Xenopus antibody|Anti-BAT3 antibody (Phycoerythrin) [EPR9223]

SCBT cat No: sc-82528|sc-365928|sc-98519|

Name

Rabbit polyclonal BAG6 antibody

Catalogue No.

A2010

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human BAG6

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 119kDa/Observed: Refer to figures

Formulation

BAG6 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

BAG6 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

G3 antibody, BAT3 antibody, BAG-6 antibody, D6S52E antibody

Database links

Human UniProt/Swiss-Prot:P46379

Protein names

G3, BAT3, BAG-6, D6S52E

Protein function

Chaperone that plays a key role in various processes such as apoptosis, insertion of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane and regulation of chromatin. Key component of the BAG6/BAT3 complex, a cytosolic multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. BAG6/BAT3 acts by facilitating TA membrane proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins and transfers them to ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane. Moreover, it regulates the stability and the degradation of proteins by the proteasome. For instance, it is required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, may play a role in immuno-proteasomes to generate antigenic peptides via targeted degradation, thereby playing a role in antigen presentation in immune response. It is also involved in ubiquitin-mediated proteasomal degradation of proteins of the secretory pathway that are mislocalized to the cytosol. Binds the mislocalized proteins, preventing their aggregation in the cytosol, and promotes their ubiquitination. Participates in endoplasmic reticulum stress-induced apoptosis via its interaction with AIFM1/AIF by regulating AIFM1/AIF stability and preventing its degradation. Also required during spermatogenesis for synaptonemal complex assembly via its interaction with HSPA2, by inhibiting polyubiquitination and subsequent proteasomal degradation of HSPA2.; Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 ‘Lys-4’ dimethylation (H3K4me2).; Can be released from tumor and dendritic cells in membrane vesicles or exosomes, and engage NCR3 thereby promoting natural killer cells (NK) activation and cytotoxicity.

Protein sequence and domain

Contains 1 ubiquitin-like domain.

Protein post-translational modifications

Cleavage by caspase-3 releases a C-terminal peptide that plays a role in ricin-induced apoptosis.; In case of infection by L.pneumophila, ubiquitinated by the SCF(LegU1) complex.

Protein cellular localization

Cytoplasm, cytosol. Nucleus. Note: The C-terminal fragment generated by caspase-3 is cytoplasmic. Also found in extracellular vesicular exosomes in some tumor cells.

Background

This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Tumor Suppressor/Apoptosis>Bag
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize BAG6 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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