Rabbit polyclonal BAIAP2 antibody (A5337)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal BAIAP2 antibody (A5337)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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BAP2 antibody, FLAF3 antibody, IRSP53 antibody
BAI-associated protein 2 antibody|BAI1 associated protein 2 antibody|BAI1-associated protein 2 antibody|BAIAP 2 antibody|Baiap2 antibody|BAIP2_HUMAN antibody|BAP2 antibody|Brain-specific angiogenesis inhibitor 1-associated protein 2 antibody|Fas ligand-associated factor 3 antibody|FLAF3 antibody|Insulin receptor substrate p53 antibody|Insulin receptor substrate p53/p58 antibody|Insulin receptor substrate protein of 53 kDa antibody|IRS-58 antibody|IRSp53 antibody|IRSp53/58 antibody|Protein BAP2 antibody|Anti-BAIAP2 antibody (ab126057)

SCBT cat No: sc-136470|sc-50008|sc-134810|sc-50011|

Name

Rabbit polyclonal BAIAP2 antibody

Catalogue No.

A5337

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human BAIAP2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 61kDa/Observed: Refer to Figures

Formulation

BAIAP2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

BAIAP2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BAP2 antibody, FLAF3 antibody, IRSP53 antibody

Database links

Human UniProt/Swiss-Prot:Q9UQB8

Protein names

BAP2, FLAF3, IRSP53

Protein function

Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.

Protein tissue specificity

Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta.

Protein sequence and domain

The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation.; The SH3 domain interacts with ATN1, BAI1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH.Contains 1 IMD (IRSp53/MIM homology) domain.; Contains 1 SH3 domain.

Protein post-translational modifications

Phosphorylated on tyrosine residues by INSR in response to insulin treatment.

Protein cellular localization

Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note: Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.

Background

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Note

AntibodyPlus can customize BAIAP2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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