Rabbit polyclonal BAX antibody (A7626)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal BAX antibody (A7626)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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BCL2L4 antibody
Apoptosis regulator BAX antibody|BAX antibody|Bax-protein antibody|BAX_HUMAN antibody|BAXA antibody|Baxdelta2G9 antibody|Baxdelta2G9omega antibody|Baxdelta2omega antibody|Bcl-2-like protein 4 antibody|BCL2 associated X protein antibody|BCL2 associated X protein omega antibody|BCL2 associated X protein transcript variant delta2 antibody|Bcl2-L-4 antibody|BCL2L4 antibody|membrane isoform alpha antibody|Anti-Bax antibody [E63] (ab32503)

SCBT cat No: sc-6236|sc-20067|sc-70407|sc-23959|sc-70405|sc-70408|sc-7480|sc-493|sc-526|sc-65532|sc-80658|sc-20288|

Name

Rabbit polyclonal BAX antibody

Catalogue No.

A7626

Reactivity

Human

Immunogen

A synthetic peptide of human BAX

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 21kDa/Observed: Refer to Figures

Formulation

BAX antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

BAX antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BCL2L4 antibody

Database links

Human UniProt/Swiss-Prot:Q07812

Protein names

BCL2L4

Protein function

Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Protein tissue specificity

Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt’s lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.

Protein sequence and domain

Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.Belongs to the Bcl-2 family.

Protein cellular localization

Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note: Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane.; Isoform Beta: Cytoplasm.; Isoform Gamma: Cytoplasm.; Isoform Delta: Cytoplasm .

Background

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Research area

All research areas>Tumor Suppressor/Apoptosis>Bax
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize BAX antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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