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Rabbit polyclonal BAZ1B antibody (A9851)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal BAZ1B antibody.
Check alternative names for the antibodyExpand
baz1b antibody|BAZ1B_HUMAN antibody|Bromodomain adjacent to zinc finger domain protein 1B antibody|hWALP 2 antibody|hWALP-2 antibody|hWALP2 antibody|transcription factor WSTF antibody|Tyrosine-protein kinase BAZ1B antibody|WALP-2 antibody|WALP2 antibody|WBRS 9 antibody|WBRS-9 antibody|WBRS9 antibody|WBSC 10 antibody|WBSC-10 antibody|WBSC10 antibody|WBSCR10 antibody|WBSCR9 antibody|Williams Beuren syndrome chromosome region 9 protein antibody|Williams syndrome transcription factor antibody|Williams-Beuren syndrome chromosomal region 10 protein antibody|Williams-Beuren syndrome chromosomal region 9 protein antibody|WSTF antibody|Anti-WSTF antibody [EP1704Y] (ab51256)
SCBT cat No:
Rabbit polyclonal BAZ1B antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human BAZ1B
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 171kDa/Observed: Refer to figures
BAZ1B antibody was tube-contained.
BAZ1B antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating ‘Tyr-142’ of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at ‘Tyr-142’, and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.
|Protein tissue specificity|| |
Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary.
|Protein sequence and domain|| |
The N-terminal part (1-345), including the WAC domain and the C motif, mediates the tyrosine-protein kinase activity.; The bromo domain mediates the specific interaction with acetylated histones.Belongs to the WAL family. BAZ1B subfamily.; Contains 1 bromo domain.; Contains 1 DDT domain.; Contains 1 PHD-type zinc finger.; Contains 1 WAC domain.
|Protein cellular localization|| |
Nucleus . Note: Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA.
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|Product type|| |
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