Rabbit polyclonal BAZ1B antibody (A9851)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal BAZ1B antibody (A9851)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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SCBT cat No:

Name

Rabbit polyclonal BAZ1B antibody

Catalogue No.

A9851

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human BAZ1B

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 171kDa/Observed: Refer to figures

Formulation

BAZ1B antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

BAZ1B antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:Q9UIG0

Protein function

Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating ‘Tyr-142’ of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at ‘Tyr-142’, and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.

Protein tissue specificity

Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary.

Protein sequence and domain

The N-terminal part (1-345), including the WAC domain and the C motif, mediates the tyrosine-protein kinase activity.; The bromo domain mediates the specific interaction with acetylated histones.Belongs to the WAL family. BAZ1B subfamily.; Contains 1 bromo domain.; Contains 1 DDT domain.; Contains 1 PHD-type zinc finger.; Contains 1 WAC domain.

Protein cellular localization

Nucleus . Note: Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA.

Note

AntibodyPlus can customize BAZ1B antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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