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Rabbit polyclonal BCCIP antibody (A8586)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:100 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal BCCIP antibody.
Check alternative names for the antibodyExpand
TOK1 antibody, TOK-1 antibody
bccip antibody|BCCIP_HUMAN antibody|BCCIPalpha antibody|BCCIPbeta antibody|BRCA2 and CDKN1A interacting protein antibody|BRCA2 and CDKN1A-interacting protein antibody|BRCA2 and Cip1/p21 interacting protein antibody|Cdk inhibitor p21 binding protein antibody|P21 and CDK associated protein 1 antibody|P21- and CDK-associated protein 1 antibody|Protein TOK-1 antibody|Protein TOK1 antibody|TOK 1 antibody|TOK 1alpha antibody|TOK 1beta antibody|TOK1 antibody|Anti-BCCIP antibody (ab168157)
SCBT cat No:
Rabbit polyclonal BCCIP antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human BCCIP
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 36kDa/Observed: Refer to figures
BCCIP antibody was tube-contained.
BCCIP antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
TOK1 antibody, TOK-1 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
|Protein tissue specificity|| |
Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen.
|Protein sequence and domain|| |
Belongs to the BCP1 family.
|Protein cellular localization|| |
Nucleus . Note: Colocalizes with BRCA2 in discrete nuclear foci.
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.
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|Product type|| |
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