Rabbit polyclonal BCCIP antibody (A8586)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal BCCIP antibody (A8586)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

TOK1 antibody, TOK-1 antibody
bccip antibody|BCCIP_HUMAN antibody|BCCIPalpha antibody|BCCIPbeta antibody|BRCA2 and CDKN1A interacting protein antibody|BRCA2 and CDKN1A-interacting protein antibody|BRCA2 and Cip1/p21 interacting protein antibody|Cdk inhibitor p21 binding protein antibody|P21 and CDK associated protein 1 antibody|P21- and CDK-associated protein 1 antibody|Protein TOK-1 antibody|Protein TOK1 antibody|TOK 1 antibody|TOK 1alpha antibody|TOK 1beta antibody|TOK1 antibody|Anti-BCCIP antibody (ab168157)

SCBT cat No:

Name

Rabbit polyclonal BCCIP antibody

Catalogue No.

A8586

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human BCCIP

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:100 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 36kDa/Observed: Refer to figures

Formulation

BCCIP antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

BCCIP antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

TOK1 antibody, TOK-1 antibody

Database links

Human UniProt/Swiss-Prot:Q9P287

Protein names

TOK1, TOK-1

Protein function

May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).

Protein tissue specificity

Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen.

Protein sequence and domain

Belongs to the BCP1 family.

Protein cellular localization

Nucleus . Note: Colocalizes with BRCA2 in discrete nuclear foci.

Background

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

Research area

All research areas>Signaling Intermediates>TOK-1
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize BCCIP antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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