Rabbit polyclonal BCL10 antibody (A1106)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal BCL10 antibody (A1106)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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BCL10 antibody,CARMEN antibody,CIPER antibody,CLAP antibody,c-E10 antibody,mE10 antibody
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SCBT cat No: sc-56023|sc-5273|sc-32808|sc-13153|sc-9560|sc-5611|sc-55511|sc-9558|sc-33093|

Name

Rabbit polyclonal BCL10 antibody

Catalogue No.

A1106

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human BCL10

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 26kDa/Observed: Refer to Figures

Formulation

BCL10 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

BCL10 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BCL10 antibody,CARMEN antibody,CIPER antibody,CLAP antibody,c-E10 antibody,mE10 antibody

Database links

Human UniProt/Swiss-Prot:O95999

Protein names

BCL10,CARMEN,CIPER,CLAP,c-E10,mE10

Protein function

Involved in adaptive immune response . Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 .

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

Contains 1 CARD domain.

Protein post-translational modifications

Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB.

Protein cellular localization

Cytoplasm, perinuclear region . Membrane raft . Note: Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.

Background

Bcl10/CIPER/CLAP/mE10 is a widely expressed CARD (caspase recruitment domain) containing protein shown to induce apoptosis and activate NF-kappaB (1-5). The CARD domain mediates self-oligomerization, interactions with other CARD proteins and is necessary for NF-kappaB activation, although the precise mechanism which Bcl10 regulates these processes is not fully understood. The discovery of Bcl10 came from observations of the chromosomal translocation t(1;14)(p22;q32) from B cell lymphomas of the mucosa-associated lymphoid tissue (MALT) (1,5). This translocation results in deregulated expression of a truncated form of Bcl10 which lacks apoptotic activity and enhances transformation. Studies from Bcl10 deficient mice demonstrate that Bcl10 is essential for the activation of NF-kappaB by T- and B-cell receptors (6). One third of Bcl10 deficient mice developed lethal exencephaly. Surviving mice were unaffected by various apoptotic stimuli, but were severely immunodeficient and defective in antigen receptor-induced NF-kappaB activiation. PKC or T-cell receptor signaling results in a downregulation of Bcl10 protein levels, attenuating both NF-kappaB activation and cellular proliferation and also provides a negative feedback regulation of the NF-kappaB signaling to T cell signaling (7).

Research area

All research areas>Tumor Suppressor/Apoptosis>Bcl10
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize BCL10 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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