Rabbit Polyclonal BCL2L2 antibody (A1158)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal BCL2L2 antibody (A1158)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal BCL2L2 antibody.

Alternative names:

Check alternative names for the antibody

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BCL2L2 antibody;BCL-W antibody;BCLW antibody;KIAA0271 antibody;
Apoptosis regulator BCL W antibody|Apoptosis regulator Bcl-W antibody|B2CL2_HUMAN antibody|BCL 2 Like 2 antibody|Bcl 2 like 2 protein antibody|Bcl 2L2 antibody|BCL W antibody|Bcl-2-like protein 2 antibody|Bcl2 L2 antibody|BCL2 like 2 antibody|BCL2 like 2 protein antibody|Bcl2-L-2 antibody|Bcl2l2 antibody|BCLW antibody|KIAA0271 antibody|PPP1R51 antibody|Protein phosphatase 1 regulatory subunit 51 antibody|Anti-Bcl2L2 antibody (ab38629)

SCBT cat No: sc-293236|sc-6418|sc-130701|sc-11422|sc-6172|

Name

Rabbit Polyclonal BCL2L2 antibody

Catalogue No.

A1158

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human BCL2L2

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

21kDa

Formulation

BCL2L2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BCL2L2 antibody;BCL-W antibody;BCLW antibody;KIAA0271 antibody;

Database links

Human UniProt/Swiss-Prot:Q92843

Protein names

BCL2L2;BCL-W;BCLW;KIAA0271 ;

Protein function

Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

Protein tissue specificity

Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.

Protein sequence and domain

Belongs to the Bcl-2 family. The BH4 motif seems to be involved in the anti-apoptotic function.; The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2.

Protein cellular localization

Mitochondrion membrane ; Peripheral membrane protein . Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.

Background

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

Research area

All research areas>Tumor Suppressor/Apoptosis>Bcl-w
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize BCL2L2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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Antibody customer reviews & validation data - 64

Validation data ID: 64

Submission date: 2017-01-18

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Result figure:
Result figure

Figure description:

1. Marker
2.Hela
3.Hela
4. Hela

Product name

Rabbit polyclonal BCL2L2 antibody

Product catalog No.

A1158

Product type

Primary antibody

Supplier

ABclonal

Application type

Western Blot

Antibody specificity rating

Good

Antibody overall rating

Good

Your comments

There is good image of band,size is larger than expected. Also there is stronger incorrect size band in the background.The antibody is good for western blot.

Detailed protocol

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