Rabbit polyclonal BCR antibody (A0068)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal BCR antibody (A0068)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

ALL antibody,BCR1 antibody,CML antibody,D22S11 antibody,D22S662 antibody,PHL antibody,Breakpoint cluster region protein antibody, Renal carcinoma antigen NY-REN-26 antibody
ALL antibody|bcr antibody|BCR/ABL FUSION GENE, INCLUDED antibody|BCR/FGFR1 chimera protein antibody|BCR/FGFR1 FUSION GENE, INCLUDED antibody|BCR/PDGFRA FUSION GENE, INCLUDED antibody|BCR_HUMAN antibody|BCR1 antibody|Breakpoint cluster region antibody|Breakpoint cluster region protein antibody|CML antibody|D22S11 antibody|D22S662 antibody|FGFR1/BCR chimera protein antibody|PHL antibody|Renal carcinoma antigen NY-REN-26 antibody|Anti-Bcr antibody [EP535Y] (ab40779)

SCBT cat No: sc-53178|sc-103|sc-365728|sc-28375|sc-886|sc-104|sc-48422|sc-885|sc-134280|sc-134281|sc-99280|

Name

Rabbit polyclonal BCR antibody

Catalogue No.

A0068

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human BCR

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 130/160kDa/Observed: Refer to Figures

Formulation

BCR antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

BCR antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ALL antibody,BCR1 antibody,CML antibody,D22S11 antibody,D22S662 antibody,PHL antibody,Breakpoint cluster region protein antibody, Renal carcinoma antigen NY-REN-26 antibody

Database links

Human UniProt/Swiss-Prot:P11274

Protein names

ALL,BCR1,CML,D22S11,D22S662,PHL,Breakpoint cluster region protein, Renal carcinoma antigen NY-REN-26

Protein function

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.

Protein sequence and domain

The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene.; The DH domain is involved in interaction with CCPG1.Contains 1 C2 domain.; Contains 1 DH (DBL-homology) domain.; Contains 1 PH domain.; Contains 1 Rho-GAP domain.

Protein post-translational modifications

Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.

Protein cellular localization

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density .

Background

The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.

Research area

All research areas>Kinases and Phosphatases>Bcr
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize BCR antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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