Rabbit polyclonal BCR antibody (A0068)


Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal BCR antibody (A0068)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal BCR antibody.

Alternative names:

Check alternative names for the antibody


ALL antibody,BCR1 antibody,CML antibody,D22S11 antibody,D22S662 antibody,PHL antibody,Breakpoint cluster region protein antibody, Renal carcinoma antigen NY-REN-26 antibody
ALL antibody|bcr antibody|BCR/ABL FUSION GENE, INCLUDED antibody|BCR/FGFR1 chimera protein antibody|BCR/FGFR1 FUSION GENE, INCLUDED antibody|BCR/PDGFRA FUSION GENE, INCLUDED antibody|BCR_HUMAN antibody|BCR1 antibody|Breakpoint cluster region antibody|Breakpoint cluster region protein antibody|CML antibody|D22S11 antibody|D22S662 antibody|FGFR1/BCR chimera protein antibody|PHL antibody|Renal carcinoma antigen NY-REN-26 antibody|Anti-Bcr antibody [EP535Y] (ab40779)

SCBT cat No: sc-53178|sc-103|sc-365728|sc-28375|sc-886|sc-104|sc-48422|sc-885|sc-134280|sc-134281|sc-99280|


Rabbit polyclonal BCR antibody

Catalogue No.



Human, Mouse, Rat


Recombinant protein of human BCR





Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100







Molecular weight

Predicted: 130/160kDa/Observed: Refer to Figures


BCR antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.


BCR antibody was purified using affinity purification.


Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ALL antibody,BCR1 antibody,CML antibody,D22S11 antibody,D22S662 antibody,PHL antibody,Breakpoint cluster region protein antibody, Renal carcinoma antigen NY-REN-26 antibody

Database links

Human UniProt/Swiss-Prot:P11274

Protein names

ALL,BCR1,CML,D22S11,D22S662,PHL,Breakpoint cluster region protein, Renal carcinoma antigen NY-REN-26

Protein function

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.

Protein sequence and domain

The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene.; The DH domain is involved in interaction with CCPG1.Contains 1 C2 domain.; Contains 1 DH (DBL-homology) domain.; Contains 1 PH domain.; Contains 1 Rho-GAP domain.

Protein post-translational modifications

Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.

Protein cellular localization

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density .


The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.

Research area

All research areas>Kinases and Phosphatases>Bcr
(View all antibody categories related to Kinases and Phosphatases)


AntibodyPlus can customize BCR antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody


ABclonal Inc.


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:

Welcome to AntibodyPlus!