Rabbit polyclonal BEST1 antibody (A3022)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal BEST1 antibody (A3022)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal BEST1 antibody.

Alternative names:

Check alternative names for the antibody

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ARB antibody|BEST 1 antibody|BEST antibody|Best disease antibody|Best macular dystrophy antibody|BEST1 antibody|BEST1_HUMAN antibody|Best1V1Delta2 antibody|Bestrophin 1 antibody|Bestrophin-1 antibody|Bestrophin1 antibody|BMD antibody|mBest1 antibody|RP50 antibody|TU15B antibody|Vitelliform macular dystrophy 2 antibody|Vitelliform macular dystrophy antibody|Vitelliform macular dystrophy protein 2 antibody|VMD 2 antibody|VMD2 antibody|Anti-Bestrophin antibody [E6-6] (ab2182)

SCBT cat No: sc-22027|sc-32792|sc-292163|

Name

Rabbit polyclonal BEST1 antibody

Catalogue No.

A3022

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human BEST1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 68kDa/Observed: Refer to figures

Formulation

BEST1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

BEST1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:O76090

Protein function

Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate.

Protein tissue specificity

Predominantly expressed in the basolateral membrane of the retinal pigment epithelium.

Protein sequence and domain

Belongs to the bestrophin family.

Protein post-translational modifications

Phosphorylated by PP2A.

Protein cellular localization

Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane .

Background

This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]

Research area

All research areas>Signaling Intermediates>Bestrophin
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize BEST1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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