Rabbit polyclonal BHLHE40 antibody (A6534)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal BHLHE40 antibody (A6534)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal BHLHE40 antibody.

Alternative names:

Check alternative names for the antibody

Expand

DEC1 antibody, HLHB2 antibody, BHLHB2 antibody, STRA13 antibody, Stra14 antibody, SHARP-2 antibody
BHLHB2 antibody|SHARP 2 antibody|Stimulated by retinoic acid gene 13 protein antibody|STRA13 antibody|Anti-SHARP2 antibody (ab23797)

SCBT cat No: sc-101023|

Name

Rabbit polyclonal BHLHE40 antibody

Catalogue No.

A6534

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human BHLHE40

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 45kDa/Observed: Refer to figures

Formulation

BHLHE40 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

BHLHE40 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DEC1 antibody, HLHB2 antibody, BHLHB2 antibody, STRA13 antibody, Stra14 antibody, SHARP-2 antibody

Database links

Human UniProt/Swiss-Prot:O14503

Protein names

DEC1, HLHB2, BHLHB2, STRA13, Stra14, SHARP-2

Protein function

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1, ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5′-CACGTG-3′) found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.

Protein tissue specificity

Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach.

Protein sequence and domain

Contains 1 bHLH (basic helix-loop-helix) domain.; Contains 1 Orange domain.

Protein post-translational modifications

Ubiquitinated; which may lead to proteasomal degradation.; Sumoylation inhibits its ubiquitination and promotes its negative regulation of the CLOCK-ARNTL/BMAL1 heterodimer transcriptional activator activity.

Protein cellular localization

Cytoplasm . Nucleus . Note: Predominantly localized in the nucleus .

Background

This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL’s transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation.

Note

AntibodyPlus can customize BHLHE40 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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