Rabbit polyclonal BIRC2 antibody (A0985)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal BIRC2 antibody (A0985)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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BIRC2 antibody,API1 antibody,HIAP2 antibody,Hiap-2 antibody,MIHB antibody,RNF48 antibody,cIAP1 antibody
API 1 antibody|API1 antibody|Apoptosis inhibitor 1 antibody|Baculoviral IAP repeat containing 2 antibody|Baculoviral IAP repeat containing protein 2 antibody|Baculoviral IAP repeat-containing protein 2 antibody|BIRC 2 antibody|BIRC2 antibody|BIRC2_HUMAN antibody|C IAP1 antibody|C-IAP1 antibody|cIAP 1 antibody|cIAP1 antibody|HIAP 2 antibody|HIAP-2 antibody|HIAP2 antibody|IAP 2 antibody|IAP homolog B antibody|IAP-2 antibody|IAP2 antibody|Inhibitor of apoptosis protein 2 antibody|MIHB antibody|NFR2 TRAF signalling complex protein antibody|RING finger protein 48 antibody|RNF 48 antibody|RNF48 antibody|TNFR2 TRAF signaling complex protein 2 antibody|TNFR2-TRAF-signaling complex protein 2 antibody|Anti-cIAP1 antibody (ab2399)

SCBT cat No: sc-271419|sc-7943|sc-1867|sc-12410|

Name

Rabbit polyclonal BIRC2 antibody

Catalogue No.

A0985

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human BIRC2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 70kDa/Observed: Refer to Figures

Formulation

BIRC2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

BIRC2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BIRC2 antibody,API1 antibody,HIAP2 antibody,Hiap-2 antibody,MIHB antibody,RNF48 antibody,cIAP1 antibody

Database links

Human UniProt/Swiss-Prot:Q13490

Protein names

BIRC2,API1,HIAP2,Hiap-2,MIHB,RNF48,cIAP1

Protein function

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

Protein tissue specificity

Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.

Protein sequence and domain

The BIR domains mediate nuclear localization.; The CARD domain is necessary to stabilize the protein and inhibit the activation of E3 ubiquitin-protein ligase activity of BIRC2/c-IAP1 by preventing RING domain dimerization and E2 ubiquitin donor binding and activation.Belongs to the IAP family.; Contains 3 BIR repeats.; Contains 1 CARD domain.; Contains 1 RING-type zinc finger.

Protein post-translational modifications

Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.

Protein cellular localization

Cytoplasm. Nucleus. Note: Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.

Background

The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR (baculovirus inhibitor repeat) domain (1,2). Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression (3-5). In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9 (5,6). In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase (2).

Note

AntibodyPlus can customize BIRC2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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