Rabbit polyclonal BIRC7 antibody (A5736)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal BIRC7 antibody (A5736)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal BIRC7 antibody.

Alternative names:

Check alternative names for the antibody

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KIAP antibody, LIVIN antibody, MLIAP antibody, RNF50 antibody, ML-IAP antibody
Baculoviral IAP repeat containing 7 antibody|Baculoviral IAP repeat containing protein 7 antibody|Baculoviral IAP repeat-containing protein 7 antibody|BIRC 7 antibody|birc7 antibody|BIRC7_HUMAN antibody|KIAP antibody|Kidney inhibitor of apoptosis protein antibody|Livin antibody|Livin inhibitor of apotosis antibody|Melanoma inhibitor of apoptosis protein antibody|ML IAP antibody|ML-IAP antibody|MLIAP antibody|RING finger protein 50 antibody|RNF 50 antibody|RNF50 antibody|Anti-Livin antibody (ab97350)

SCBT cat No: sc-71592|sc-166390|sc-393237|sc-30161|

Name

Rabbit polyclonal BIRC7 antibody

Catalogue No.

A5736

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human BIRC7

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 32kDa/Observed: Refer to Figures

Formulation

BIRC7 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

BIRC7 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

KIAP antibody, LIVIN antibody, MLIAP antibody, RNF50 antibody, ML-IAP antibody

Database links

Human UniProt/Swiss-Prot:Q96CA5

Protein names

KIAP, LIVIN, MLIAP, RNF50, ML-IAP

Protein function

Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.

Protein tissue specificity

Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.

Protein sequence and domain

The RING domain is essential for autoubiquitination.Belongs to the IAP family.; Contains 1 BIR repeat.; Contains 1 RING-type zinc finger.

Protein post-translational modifications

Autoubiquitinated and undergoes proteasome-mediated degradation.; The truncated protein (tLivin) not only loses its anti-apoptotic effect but also acquires a pro-apoptotic effect.

Protein cellular localization

Nucleus . Cytoplasm . Golgi apparatus . Note: Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.

Background

This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants

Research area

All research areas>Tumor Suppressor/Apoptosis>ML-IAP
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize BIRC7 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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