Rabbit polyclonal BMPR1A antibody (A1816)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal BMPR1A antibody (A1816)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal BMPR1A antibody.

Alternative names:

Check alternative names for the antibody

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ALK3 antibody, SKR5 antibody, CD292 antibody, ACVRLK3 antibody, 10q23del antibody
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SCBT cat No:

Name

Rabbit polyclonal BMPR1A antibody

Catalogue No.

A1816

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human BMPR1A

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 60kDa/Observed: Refer to Figures

Formulation

BMPR1A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

BMPR1A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ALK3 antibody, SKR5 antibody, CD292 antibody, ACVRLK3 antibody, 10q23del antibody

Database links

Human UniProt/Swiss-Prot:P36894

Protein names

ALK3, SKR5, CD292, ACVRLK3, 10q23del

Protein function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.

Protein tissue specificity

Highly expressed in skeletal muscle.

Protein sequence and domain

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.; Contains 1 GS domain.; Contains 1 protein kinase domain.

Protein cellular localization

Membrane; Single-pass type I membrane protein.

Background

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

Research area

All research areas>Membrane Receptors>BMP Receptor
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize BMPR1A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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