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Rabbit polyclonal BNIP3 antibody (A5683)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal BNIP3 antibody.
Check alternative names for the antibodyExpand
BCL2 Adenovirus E1B 19kDa Interacting Protein 3 antibody|BCL2/adenovirus E1B 19 kDa protein interacting protein 3 antibody|BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 antibody|BNIP 3 antibody|BNIP3 antibody|BNIP3_HUMAN antibody|NIP 3 antibody|NIP3 antibody|Anti-BNIP3 antibody [ANa40] (ab10433)
SCBT cat No: sc-56167|sc-1715|
Rabbit polyclonal BNIP3 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human BNIP3
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 21kDa/Observed: Refer to Figures
BNIP3 antibody was tube-contained.
BNIP3 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
|Protein sequence and domain|| |
Belongs to the NIP3 family.
|Protein cellular localization|| |
Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note: Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane.
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2.
AntibodyPlus can customize BNIP3 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
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Antibody customer reviews & validation data - 145
Validation data ID: 145
Submission date: 2017-03-08
We see a darker band around 21kD in lane 2 (CoCl2-treated C2C12) than in lane 1 (untreated C2C12) as expected, but the band is weaker and the background is higher than a competitor's antibody. No convincing bands seen at the expected size in the other lanes.
Rabbit polyclonal BNIP3 antibody
Product catalog No.
Antibody specificity rating
Antibody overall rating
This product showed weaker bands and higher background than a competitor's antibody when run side-by-side with the same samples.
We expect Bnip3 expression in the CoCl2-treated C2C12 sample
There is no extra validation for this product yet.
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