Rabbit polyclonal BPGM antibody (A7880)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal BPGM antibody (A7880)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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DPGM antibody
2 antibody|2,3-bisphosphoglycerate mutase antibody|2,3-bisphosphoglycerate mutase, erythrocyte antibody|2,3-bisphosphoglycerate synthase antibody|2,3-diphosphoglycerate mutase antibody|3-bisphosphoglycerate mutase antibody|3-bisphosphoglycerate synthase antibody|3-diphosphoglycerate mutase antibody|Ab2 098 antibody|AI323730 antibody|AL022789 antibody|Bisphosphoglycerate mutase antibody|BPG dependent PGAM antibody|BPG-dependent PGAM antibody|Bpgm antibody|C86192 antibody|DPGM antibody|Erythrocyte 2,3 bisphosphoglycerate mutase antibody|erythrocyte antibody|PMGE_HUMAN antibody|Anti-BPGM antibody (ab97497)

SCBT cat No: sc-393964|sc-373819|sc-376578|sc-82787|

Name

Rabbit polyclonal BPGM antibody

Catalogue No.

A7880

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human BPGM

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 30kDa/Observed: Refer to figures

Formulation

BPGM antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

BPGM antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DPGM antibody

Database links

Human UniProt/Swiss-Prot:P07738

Protein names

DPGM

Protein function

Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities.

Protein tissue specificity

Expressed in red blood cells. Expressed in non-erythroid cells of the placenta; present in the syncytiotrophoblast layer of the placental villi at the feto-maternal interface (at protein level).

Protein sequence and domain

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Protein post-translational modifications

Glycation of Lys-159 in diabetic patients inactivates the enzyme.

Background

2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Note

AntibodyPlus can customize BPGM antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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