Rabbit Polyclonal BPIFA1 antibody (A8634)

$99.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal BPIFA1 antibody (A8634)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

LUNX antibody; NASG antibody; PLUNC antibody; SPURT antibody; SPLUNC1 antibody; bA49G10.5
BPIFA1 antibody|Palate lung and nasal epithelium clone protein antibody|PLUNC antibody|Protein Plunc antibody|Secretory protein in upper respiratory tracts antibody|SPLUNC1 antibody|SPURT antibody|Tracheal epithelium-enriched protein antibody|Von Ebner protein Hl antibody|Anti-Plunc antibody [EPR8381] (ab131163)

SCBT cat No: sc-398376|sc-398364|sc-133917|

Name

Rabbit Polyclonal BPIFA1 antibody

Catalogue No.

A8634

Reactivity

Human

Immunogen

Recombinant protein of human BPIFA1

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

27kDa

Formulation

BPIFA1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

LUNX antibody; NASG antibody; PLUNC antibody; SPURT antibody; SPLUNC1 antibody; bA49G10.5

Protein names

LUNX; NASG; PLUNC; SPURT; SPLUNC1; bA49G10.5

Protein function

Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression.

Protein tissue specificity

Lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium. Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues. Highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways. Also expressed in lung cancers and some other types of cancer.

Protein sequence and domain

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.

Protein post-translational modifications

May be N-glycosylated.

Protein cellular localization

Secreted . Note=Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.

Background

This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Lymphocyte-Signaling/">Lymphocyte Signaling</a>><a href="http://antibodyplus.com/product-tag/PLUNC/">PLUNC</a><br><a href="http://antibodyplus.com/product-tag/Lymphocyte-Signaling/"&gt; (View all antibody categories related to Lymphocyte Signaling)</a>

Note

AntibodyPlus can customize BPIFA1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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