Rabbit polyclonal BSND antibody (A7747)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal BSND antibody (A7747)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

BART antibody, DFNB73 antibody
BART antibody|Bartter syndrome infantile with sensorineural deafness antibody|Bartter syndrome, infantile, with sensorineural deafness (Barttin) antibody|Barttin antibody|Bsnd antibody|BSND_HUMAN antibody|deafness, autosomal recessive 73 antibody|DFNB 73 antibody|DFNB73 antibody|Anti-BSND antibody [EPR14270] – C-terminal (ab196017)

SCBT cat No: sc-271867|sc-365161|sc-49611|

Name

Rabbit polyclonal BSND antibody

Catalogue No.

A7747

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human BSND

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 35kDa/Observed: Refer to figures

Formulation

BSND antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

BSND antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BART antibody, DFNB73 antibody

Database links

Human UniProt/Swiss-Prot:Q8WZ55

Protein names

BART, DFNB73

Protein function

Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter.

Protein tissue specificity

Expressed primarily in kidney. Expressed in specific nephron segments and in the stria vascularis of the inner ear.

Protein post-translational modifications

Palmitoylation is necessary for activation of plasma membrane-inserted CLC-K/barttin channels.

Protein cellular localization

Cell membrane ; Multi-pass membrane protein . Cytoplasm . Note: A significant amount also observed intracellularly. Staining in membranes of the renal tubule and of potassium-secreting epithelia of the inner ear is basolateral (By similarity).

Background

This gene encodes an essential beta subunit for CLC chloride channels. These heteromeric channels localize to basolateral membranes of renal tubules and of potassium-secreting epithelia of the inner ear. Mutations in this gene have been associated with Bartter syndrome with sensorineural deafness.

Note

AntibodyPlus can customize BSND antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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