Rabbit polyclonal BTRC antibody (A1656)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal BTRC antibody (A1656)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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BETA-TRCP antibody, FBW1A antibody, FBXW1 antibody, FBXW1A antibody, FWD1 antibody, MGC4643 antibody, bTrCP antibody, bTrCP1 antibody, betaTrCP antibody
Beta transducin repeat containing E3 ubiquitin protein ligase antibody|beta TrCP1 antibody|beta-transducin repeat containing antibody|BETA-TRCP antibody|betaTrCP antibody|btrC antibody|bTrCP antibody|bTrCP1 antibody|E3RSIkappaB antibody|F box and WD repeat protein 1B antibody|F box and WD repeats protein beta TrCP antibody|F-box and WD repeats protein beta-TrCP antibody|F-box/WD repeat protein 1A antibody|F-box/WD repeat-containing protein 1A antibody|FBW1A antibody|FBW1A_HUMAN antibody|FBXW1 antibody|FBXW1A antibody|FWD1 antibody|HOS antibody|mKIAA4123 antibody|pIkappaBalpha-E3 receptor subunit antibody|Slimb antibody|Anti-Beta TRCP antibody (ab71753)

SCBT cat No: sc-390629|sc-33213|sc-8862|sc-8863|sc-166492|

Name

Rabbit polyclonal BTRC antibody

Catalogue No.

A1656

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human BTRC

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 69kDa/Observed: Refer to Figures

Formulation

BTRC antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

BTRC antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BETA-TRCP antibody, FBW1A antibody, FBXW1 antibody, FBXW1A antibody, FWD1 antibody, MGC4643 antibody, bTrCP antibody, bTrCP1 antibody, betaTrCP antibody

Database links

Human UniProt/Swiss-Prot:Q9Y297

Protein names

BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, MGC4643, bTrCP, bTrCP1, betaTrCP

Protein function

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at ‘Lys-21’ and ‘Lys-22’. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis . SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.

Protein tissue specificity

Expressed in epididymis (at protein level).

Protein sequence and domain

The N-terminal D domain mediates homodimerization.Contains 1 F-box domain.; Contains 7 WD repeats.

Protein cellular localization

Cytoplasm . Nucleus .

Background

beta-transducin repeat-containing protein (beta-TrCP or FBW1A) is an F-box family protein characterized by the presence of the protein-protein mediating F-box domain first described in cyclin F. F-box proteins act as substrate adaptors that target proteins containing a specific phosphorylated sequence element, referred to as a phosphodegron, to the SCF E3 ubiquitin ligase complex for ubiquitination (1,2). beta-TrCP targets many important proteins with diverse functions, such as p53, H-Ras, Smad4, IkappaBalpha, beta-catenin, and the cell cycle checkpoint protein claspin, for ubiquitin-mediated degradation (3-5). Research studies have shown that inhibition of beta-TrCP expression has a demonstrated benefit in the treatment of prostate cancer (6).

Note

AntibodyPlus can customize BTRC antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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