Rabbit polyclonal C3 antibody (A6879)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal C3 antibody (A6879)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ASP antibody, C3a antibody, C3b antibody, AHUS5 antibody, ARMD9 antibody, CPAMD1 antibody, HEL-S-62p antibody
acylation-stimulating protein cleavage product antibody|AHUS5 antibody|ARMD9 antibody|ASP antibody|C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 antibody|C3 antibody|C3a anaphylatoxin antibody|C3a antibody|C3b antibody|CO3_HUMAN antibody|Complement C3 antibody|Complement C3c alpha’ chain fragment 2 antibody|Complement C3c antibody|Complement component 3 antibody|Complement component C3 antibody|Complement component C3a antibody|Complement component C3b antibody|Complement factor 3 antibody|CPAMD1 antibody|Prepro C3 antibody|Anti-C3 / C3b antibody [755] (ab11871)

SCBT cat No: sc-47687|sc-514196|sc-100912|sc-163638|sc-377372|sc-137277|sc-365987|sc-365721|sc-515293|sc-515343|sc-376333|sc-376364|sc-514988|sc-99766|

Name

Rabbit polyclonal C3 antibody

Catalogue No.

A6879

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human C3

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 187kDa/Observed: Refer to figures

Formulation

C3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

C3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ASP antibody, C3a antibody, C3b antibody, AHUS5 antibody, ARMD9 antibody, CPAMD1 antibody, HEL-S-62p antibody

Database links

Human UniProt/Swiss-Prot:P01024

Protein names

ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p

Protein function

C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.; Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.; C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation.; Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 .

Protein tissue specificity

Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods.

Protein sequence and domain

Contains 1 anaphylatoxin-like domain.; Contains 1 NTR domain.

Protein post-translational modifications

C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha’ chain fragment 1 + alpha’ chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g. C3a is further processed by carboxypeptidases to release the C-terminal arginine residue generating the acylation stimulating protein (ASP). Levels of ASP are increased in adipocytes in the postprandial period and by insulin and dietary chylomicrons.; Phosphorylated by FAM20C in the extracellular medium.

Protein cellular localization

Secreted.

Background

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection.

Research area

All research areas>Lymphocyte Signaling>Complement Pathway Protein
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize C3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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