Rabbit polyclonal C4BPB antibody (A6362)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal C4BPB antibody (A6362)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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C4BP antibody
C4b binding protein beta chain antibody|C4b-binding protein beta chain antibody|C4BP antibody|C4BPB antibody|C4BPB_HUMAN antibody|Complement component 4 binding protein beta antibody|Complement component 4 binding protein beta chain antibody|Complement component 4-binding protein beta antibody|OTTHUMP00000034288 antibody|OTTHUMP00000034289 antibody|OTTHUMP00000034375 antibody|OTTHUMP0000003474 antibody|Proline rich protein antibody|PRP antibody|Anti-C4 binding protein antibody [EPR17101] (ab199430)

SCBT cat No: sc-65970|sc-17214|sc-398720|sc-292601|

Name

Rabbit polyclonal C4BPB antibody

Catalogue No.

A6362

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human C4BPB

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 28kDa/Observed: Refer to Figures

Formulation

C4BPB antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

C4BPB antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

C4BP antibody

Database links

Human UniProt/Swiss-Prot:P20851

Protein names

C4BP

Protein function

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.

Protein sequence and domain

Contains 3 Sushi (CCP/SCR) domains.

Protein cellular localization

Secreted.

Background

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.

Note

AntibodyPlus can customize C4BPB antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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