Rabbit polyclonal C5 antibody (A8104)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal C5 antibody (A8104)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

C5D antibody, C5a antibody, C5b antibody, ECLZB antibody, CPAMD4 antibody
Anaphylatoxin C5a analog antibody|C5 antibody|C5a anaphylatoxin antibody|Complement C5 precursor antibody|Complement component 5 antibody|Complement component C5a antibody|CPAMD 4 antibody|CPAMD4 antibody|MGC142298 antibody|Anti-C5a / C5a des Arg antibody [2942] (ab11877)

SCBT cat No: sc-58933|sc-58934|sc-52635|sc-52636|sc-52637|sc-70476|sc-21944|sc-21940|sc-398247|sc-20136|sc-52633|sc-52634|sc-21941|

Name

Rabbit polyclonal C5 antibody

Catalogue No.

A8104

Reactivity

Human

Immunogen

Recombinant protein of human C5

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 188kDa/Observed: Refer to figures

Formulation

C5 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

C5 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

C5D antibody, C5a antibody, C5b antibody, ECLZB antibody, CPAMD4 antibody

Database links

Human UniProt/Swiss-Prot:P01031

Protein names

C5D, C5a, C5b, ECLZB, CPAMD4

Protein function

Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.; Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes . C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

Protein sequence and domain

Contains 1 anaphylatoxin-like domain.; Contains 1 NTR domain.

Protein cellular localization

Secreted.

Background

The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.

Note

AntibodyPlus can customize C5 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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