Rabbit polyclonal CA2 antibody (A1440)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CA2 antibody (A1440)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

CAC antibody, CAII antibody, Car2 antibody, CA-II antibody
CA 2 antibody|CA II antibody|CA-II antibody|Ca2 antibody|CAC antibody|CAH2_HUMAN antibody|CAII antibody|Car 2 antibody|Car2 antibody|Carbonate dehydratase II antibody|Carbonic anhydrase 2 antibody|Carbonic anhydrase B antibody|Carbonic anhydrase C antibody|Carbonic anhydrase C, formerly antibody|Carbonic anhydrase II antibody|Carbonic dehydratase antibody|epididymis luminal protein 76 antibody|Epididymis secretory protein Li 282 antibody|HEL-76 antibody|HEL-S-282 antibody|Anti-Carbonic Anhydrase II antibody (ab191343)

SCBT cat No: sc-166547|sc-17246|sc-166569|sc-133111|sc-48351|sc-133110|sc-25596|sc-17244|sc-17242|

Name

Rabbit polyclonal CA2 antibody

Catalogue No.

A1440

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CA2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 29kDa/Observed: Refer to Figures

Formulation

CA2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CA2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CAC antibody, CAII antibody, Car2 antibody, CA-II antibody

Database links

Human UniProt/Swiss-Prot:P00918

Protein names

CAC, CAII, Car2, CA-II

Protein function

Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.

Protein sequence and domain

Belongs to the alpha-carbonic anhydrase family.; Contains 1 alpha-carbonic anhydrase domain.

Protein cellular localization

Cytoplasm . Cell membrane . Note: Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells.

Background

Carbonic anhydrases (CA) are a family of ancient zinc metalloenzymes found in almost all living organisms. All CA can be divided into 3 distinct classes (alpha, beta, and gamma) that evolved independently and have no significant homology in sequence and overall folding. All functional CA catalyze the reversible hydration of CO2 into HCO3- and H+ and contain a zinc atom in the active sites essential for catalysis. There are many isoforms of CA in mammals and they all belong to the alpha class (1,2).CA2 is a cytosolic member of the alpha class. It is the most widely distributed isoform among the mammalian CAs (1). Defects in CA2 are associated with osteopetrosis and renal tubular acidosis (3-5). Elevated expression of CA2 is observed in patients with Alzheimer’s disease and the developing brains of Down syndrome patients (6,7). CA2 is also overexpressed in Gastrointestinal Stromal Tumors (GISTs) and is considered a useful marker for diagnosis (8). Recently, CA2 was reported to facilitate transporter activity of the monocarboxylate transporter isoform 1 and 4 (MCT1/4) independent of its own catalytic activity (9,10)

Research area

All research areas>Synthesis and Degradation>Carbonic Anhydrases
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize CA2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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