Rabbit Polyclonal CABLES1 antibody (A10335)

$99.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal CABLES1 antibody (A10335)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:1000 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

CABL1 antibody; IK3-1 antibody; CABLES antibody; HsT2563 antibody;
CABL1_HUMAN antibody|CABLES antibody|Cables1 antibody|Cdk5 and Abl enzyme substrate 1 antibody|CDK5 and ABL1 enzyme substrate 1 antibody|FLJ35924 antibody|HsT2563 antibody|IK3 1 antibody|Ik3-1 antibody|Interactor with CDK3 1 antibody|Anti-CABLES1 antibody (ab75535)

SCBT cat No: sc-33597|

Name

Rabbit Polyclonal CABLES1 antibody

Catalogue No.

A10335

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human CABLES1

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

68kDa

Formulation

CABLES1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CABL1 antibody; IK3-1 antibody; CABLES antibody; HsT2563 antibody;

Protein names

CABL1; IK3-1; CABLES; HsT2563;

Protein function

Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).

Protein tissue specificity

Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers.

Protein sequence and domain

Belongs to the cyclin family.

Protein post-translational modifications

Phosphorylated on Ser-313 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3 (By similarity).

Protein cellular localization

Nucleus . Cytoplasm . Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity).

Background

This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Neurobiology/">Neurobiology</a>><a href="http://antibodyplus.com/product-tag/Cables1/">Cables1</a><br><a href="http://antibodyplus.com/product-tag/Neurobiology/"&gt; (View all antibody categories related to Neurobiology)</a>

Note

AntibodyPlus can customize CABLES1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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