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Rabbit Polyclonal CACNA2D2 antibody (A10267)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:200 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal CACNA2D2 antibody.
Check alternative names for the antibodyExpand
Alpha 2 delta calcium channel subunit antibody|CA2D2_HUMAN antibody|CACNA2D antibody|Cacna2d2 antibody|Calcium channel, voltage-dependent, alpha 2/delta subunit 2 antibody|Calcium channel, voltage-dependent, alpha 2/delta subunit 2 gene 26 antibody|Gene 26 antibody|KIAA0558 antibody|LUAC11.1 antibody|Voltage-dependent calcium channel subunit alpha-2/delta-2 antibody|Voltage-dependent calcium channel subunit delta-2 antibody|Voltage-gated calcium channel subunit alpha-2/delta-2 antibody|Anti-CACNA2D2 antibody [EPR12343] (ab173293)
SCBT cat No: sc-136423|sc-34768|sc-365911|sc-66822|
Rabbit Polyclonal CACNA2D2 antibody
|Catalogue No.|| |
Recombinant protein of human CACNA2D2
|Recommended dilution|| |
WB 1:200 – 1:2000
|Molecular weight|| |
CACNA2D2 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/Q9NY47">Q9NY47</a>
|Protein names|| |
|Protein function|| |
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
|Protein tissue specificity|| |
Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.
|Protein sequence and domain|| |
Belongs to the calcium channel subunit alpha-2/delta family.; Contains 1 cache domain.; Contains 1 VWFA domain. The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.
|Protein post-translational modifications|| |
May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity).
|Protein cellular localization|| |
Membrane ; Single-pass type I membrane protein . Note=Colocalizes with CACNA1A in lipid raft fractions.
Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.
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|Product type|| |
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