Rabbit Polyclonal CACNA2D2 antibody (A10267)

$99.00$259.00

Reactivity: Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal CACNA2D2 antibody (A10267)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:200 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

CACNA2D antibody;
Alpha 2 delta calcium channel subunit antibody|CA2D2_HUMAN antibody|CACNA2D antibody|Cacna2d2 antibody|Calcium channel, voltage-dependent, alpha 2/delta subunit 2 antibody|Calcium channel, voltage-dependent, alpha 2/delta subunit 2 gene 26 antibody|Gene 26 antibody|KIAA0558 antibody|LUAC11.1 antibody|Voltage-dependent calcium channel subunit alpha-2/delta-2 antibody|Voltage-dependent calcium channel subunit delta-2 antibody|Voltage-gated calcium channel subunit alpha-2/delta-2 antibody|Anti-CACNA2D2 antibody [EPR12343] (ab173293)

SCBT cat No: sc-136423|sc-34768|sc-365911|sc-66822|

Name

Rabbit Polyclonal CACNA2D2 antibody

Catalogue No.

A10267

Reactivity

Mouse, Rat

Immunogen

Recombinant protein of human CACNA2D2

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

130kDa

Formulation

CACNA2D2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CACNA2D antibody;

Protein names

CACNA2D;

Protein function

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.

Protein tissue specificity

Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.

Protein sequence and domain

Belongs to the calcium channel subunit alpha-2/delta family.; Contains 1 cache domain.; Contains 1 VWFA domain. The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.

Protein post-translational modifications

May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity).

Protein cellular localization

Membrane ; Single-pass type I membrane protein . Note=Colocalizes with CACNA1A in lipid raft fractions.

Background

Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.

Note

AntibodyPlus can customize CACNA2D2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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