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Rabbit Polyclonal CACNA2D3 antibody (A10315)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:1000 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal CACNA2D3 antibody.
Check alternative names for the antibodyExpand
CA2D3_HUMAN antibody|Cacna2d3 antibody|Calcium channel alpha2 delta3 subunit antibody|Calcium channel voltage dependent alpha 2/delta subunit 3 antibody|Calcium channel voltage-dependent alpha 2/delta 3 subunit antibody|HSA272268 antibody|Voltage dependent calcium channel subunit alpha 2/delta 3 antibody|Voltage-dependent calcium channel subunit delta-3 antibody|Voltage-gated calcium channel subunit alpha-2/delta-3 antibody|Anti-CACNA2D3 antibody (ab102939)
SCBT cat No: sc-99322|sc-99323|sc-99324|
Rabbit Polyclonal CACNA2D3 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human CACNA2D3
|Recommended dilution|| |
WB 1:1000 – 1:2000
|Molecular weight|| |
CACNA2D3 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/Q8IZS8">Q8IZS8</a>
|Protein names|| |
|Protein function|| |
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity).
|Protein tissue specificity|| |
Only detected in brain. Not present in lung, testis, aorta, spleen, jejunum, ventricular muscle and kidney (at protein level). According to PubMed:11687876, it is brain-specific, while according to PubMed:11245980, it is widely expressed.
|Protein sequence and domain|| |
Belongs to the calcium channel subunit alpha-2/delta family.; Contains 1 cache domain.; Contains 1 VWFA domain. The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.
|Protein post-translational modifications|| |
N-glycosylated.; May be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity).
|Protein cellular localization|| |
Membrane ; Single-pass type I membrane protein .
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
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|Product type|| |
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