Rabbit Polyclonal CACNA2D3 antibody (A10315)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal CACNA2D3 antibody (A10315)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:1000 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

HSA272268 antibody;
CA2D3_HUMAN antibody|Cacna2d3 antibody|Calcium channel alpha2 delta3 subunit antibody|Calcium channel voltage dependent alpha 2/delta subunit 3 antibody|Calcium channel voltage-dependent alpha 2/delta 3 subunit antibody|HSA272268 antibody|Voltage dependent calcium channel subunit alpha 2/delta 3 antibody|Voltage-dependent calcium channel subunit delta-3 antibody|Voltage-gated calcium channel subunit alpha-2/delta-3 antibody|Anti-CACNA2D3 antibody (ab102939)

SCBT cat No: sc-99322|sc-99323|sc-99324|

Name

Rabbit Polyclonal CACNA2D3 antibody

Catalogue No.

A10315

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CACNA2D3

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

123kDa

Formulation

CACNA2D3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HSA272268 antibody;

Protein names

HSA272268;

Protein function

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity).

Protein tissue specificity

Only detected in brain. Not present in lung, testis, aorta, spleen, jejunum, ventricular muscle and kidney (at protein level). According to PubMed:11687876, it is brain-specific, while according to PubMed:11245980, it is widely expressed.

Protein sequence and domain

Belongs to the calcium channel subunit alpha-2/delta family.; Contains 1 cache domain.; Contains 1 VWFA domain. The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.

Protein post-translational modifications

N-glycosylated.; May be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity).

Protein cellular localization

Membrane ; Single-pass type I membrane protein .

Background

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Note

AntibodyPlus can customize CACNA2D3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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