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Rabbit polyclonal CAD antibody (A8344)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal CAD antibody.
Check alternative names for the antibodyExpand
Aspartate carbamoyltransferase antibody|Aspartate transcarbamylase antibody|CAD protein antibody|CAD trifunctional protein antibody|Carbamoyl phosphate synthetase 2 antibody|CPSase ATCase DHOase antibody|Dihydroorotase antibody|Glutamine dependent carbamoyl phosphate synthase antibody|Multifunctional protein CAD antibody|Anti-CAD antibody [EP710Y] (ab40800)
SCBT cat No: sc-10522|sc-376072|sc-30061|sc-10521|sc-166282|sc-17290|
Rabbit polyclonal CAD antibody
|Catalogue No.|| |
Recombinant protein of human CAD
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 243kDa/Observed: Refer to figures
CAD antibody was tube-contained.
CAD antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
This protein is a “fusion” protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
|Protein sequence and domain|| |
In the central section; belongs to the DHOase family.; Contains 2 ATP-grasp domains.; Contains 1 glutamine amidotransferase type-1 domain.
|Protein post-translational modifications|| |
Activated by MAP kinase (Erk1/2) phosphorylation just prior to the S phase of the cell cycle, when the demand for pyrimidine nucleotides is greatest, and down-regulated as the cells emerge from S phase by protein kinase A (PKA) phosphorylation. Phosphorylation at Ser-1859 by RPS6KB1 downstream of MTOR promotes oligomerization and stimulates dihydroorotase activity. Phosphorylation at Ser-1406 reduces sensitivy to feedback inhibition by UTP.
|Protein cellular localization|| |
Cytoplasm . Nucleus . Note: Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.
AntibodyPlus can customize CAD antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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