Rabbit polyclonal CADM1 antibody (A1892)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CADM1 antibody (A1892)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CADM1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

BL2 antibody, ST17 antibody, IGSF4 antibody, NECL2 antibody, RA175 antibody, TSLC1 antibody, IGSF4A antibody, Necl-2 antibody, SYNCAM antibody, sgIGSF antibody, sTSLC-1 antibody, synCAM1 antibody
BL2 antibody|Cadm1 antibody|CADM1_HUMAN antibody|Cell adhesion molecule 1 antibody|DKFZp686F1789 antibody|IgSF4 antibody|IGSF4A antibody|Immunoglobulin superfamily member 4 antibody|MGC149785 antibody|MGC51880 antibody|NECL-2 antibody|NECL2 antibody|Nectin like 2 antibody|Nectin-like protein 2 antibody|RA175 antibody|SgIGSF antibody|Spermatogenic immunoglobulin superfamily antibody|ST17 antibody|sTSLC 1 antibody|Synaptic cell adhesion molecule antibody|SynCAM antibody|SynCAM1 antibody|TSLC-1 antibody|TSLC1 antibody|Tumor suppressor in lung cancer 1 antibody|Anti-SynCAM antibody (ab3910)

SCBT cat No:

Name

Rabbit polyclonal CADM1 antibody

Catalogue No.

A1892

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human CADM1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 49kDa/Observed: Refer to Figures

Formulation

CADM1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CADM1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BL2 antibody, ST17 antibody, IGSF4 antibody, NECL2 antibody, RA175 antibody, TSLC1 antibody, IGSF4A antibody, Necl-2 antibody, SYNCAM antibody, sgIGSF antibody, sTSLC-1 antibody, synCAM1 antibody

Database links

Human UniProt/Swiss-Prot:Q9BY67

Protein names

BL2, ST17, IGSF4, NECL2, RA175, TSLC1, IGSF4A, Necl-2, SYNCAM, sgIGSF, sTSLC-1, synCAM1

Protein function

Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

Protein sequence and domain

The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.Belongs to the nectin family.; Contains 2 Ig-like C2-type (immunoglobulin-like) domains.; Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Protein post-translational modifications

Glycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction.

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse . Note: Localized to the basolateral plasma membrane of epithelial cells in gall bladder.

Background

Homologous to the poliovirus receptor (PVR/CD155), the Nectin immunoglobulin superfamily comprises four known isoforms, Nectin 1, 2, 3 and 4 (also designated TSLC1). TSLC1 is encoded by a tumor-suppressor gene in human non-small-cell lung cancer mapping to chromosome 11q23.2. The TSLC1 protein is an N-linked membrane glycoprotein that co-localizes with the Actin filament-binding protein, afadin, at cadherin-based adherens junctions in MDCKII epithelial cells. TSLC1 also interacts with the tumor-suppressor gene product DAL-1 (for differentially expressed in adenocarcinoma of the lung protein 1) to target Actin rearragement and cellular motility. TSLC1 may also form homodimers that function in homophilic, intracellular adhesion. TSLC1 expression is reduced or absent in a number of characterized cancer cell lines including A549. In prostate and breast cancer, as well as in pancreatic ductal adenocarcinoma, the TSLC1 promoter is commonly silenced by hypermethylation. Unlike other Nectins, which are more widely expressed, TSLC1 is mainly expressed in the placenta.

Research area

All research areas>Cell Adhesion Proteins>TSLC
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize CADM1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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