Rabbit polyclonal CALCOCO1 antibody (A7987)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CALCOCO1 antibody (A7987)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CALCOCO1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

Cocoa antibody, PP13275 antibody, calphoglin antibody
Calcium binding and coiled coil domain 1 antibody|CALCOCO1 antibody|Calphoglin antibody|Coiled coil coactivator protein antibody|Coiled coil leucine zipper coactivator 1 antibody|Coiled coil transcriptional coactivator antibody|Inorganic pyrophosphatase activator antibody|KIAA1536 antibody|PP13275 antibody|Sarcoma antigen NY-SAR-3 antibody|Anti-CoCoA antibody (ab70564)

SCBT cat No: sc-161424|

Name

Rabbit polyclonal CALCOCO1 antibody

Catalogue No.

A7987

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human CALCOCO1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 77kDa/Observed: Refer to figures

Formulation

CALCOCO1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CALCOCO1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

Cocoa antibody, PP13275 antibody, calphoglin antibody

Database links

Human UniProt/Swiss-Prot:Q9P1Z2

Protein names

Cocoa, PP13275, calphoglin

Protein function

Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells .; Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.

Protein sequence and domain

The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity).; The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation (By similarity).; Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160 coactivators.Belongs to the CALCOCO family.

Protein cellular localization

Cytoplasm. Nucleus. Note: Shuttles between nucleus and cytoplasm.

Note

AntibodyPlus can customize CALCOCO1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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