Rabbit polyclonal CALCOCO2 antibody (A7358)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CALCOCO2 antibody (A7358)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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NDP52 antibody
Antigen nuclear dot 52 kDa protein antibody|CACO2_HUMAN antibody|Calcium binding and coiled coil domain 2 antibody|Calcium binding and coiled coil domain containing protein 2 antibody|Calcium-binding and coiled-coil domain-containing protein 2 antibody|CALCOCO 2 antibody|CALCOCO2 antibody|MGC17318 antibody|NDP52 antibody|Nuclear domain 10 protein 52 antibody|Nuclear domain 10 protein antibody|Nuclear domain 10 protein NDP52 antibody|Nuclear domain protein 52 antibody|Nuclear dot protein 52 antibody|OTTHUMP00000218344 antibody|OTTHUMP00000218345 antibody|OTTHUMP00000218346 antibody|OTTHUMP00000218347 antibody|OTTHUMP00000218349 antibody|OTTHUMP00000218351 antibody|Anti-CALCOCO2 antibody (ab68588)

SCBT cat No: sc-160994|sc-393063|sc-393042|sc-376540|

Name

Rabbit polyclonal CALCOCO2 antibody

Catalogue No.

A7358

Reactivity

Human

Immunogen

Recombinant protein of human CALCOCO2

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 52kDa/Observed: Refer to figures

Formulation

CALCOCO2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CALCOCO2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NDP52 antibody

Database links

Human UniProt/Swiss-Prot:Q13137

Protein names

NDP52

Protein function

Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting galectin-8-associated bacteria for autophagy . Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation . Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C . May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion .

Protein tissue specificity

Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain.

Protein sequence and domain

The MYO6-binding domain is required for autophagy-mediated degradation of infecting bacteria such as Salmonella typhimurium, but not for bacteria targeting to autophagosomes.; The CLIR (LC3C-interacting region) motif is required for interaction with MAP1LC3C, but dispensable for CALCOCO2-mediated autophagosome maturation.; The LIR-like motif is required for interaction with MAP1LC3A, MAP1LC3B and GABARAPL2, as well as for CALCOCO2-mediated autophagosome maturation.; The LGALS8-binding domain is essential for the recruitment to cytosol-exposed infecting bacteria.Belongs to the CALCOCO family.

Protein cellular localization

Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton . Cytoplasmic vesicle, autophagosome membrane ; Peripheral membrane protein . Note: According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus.

Background

This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Note

AntibodyPlus can customize CALCOCO2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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