Rabbit polyclonal CALHM1 antibody (A7858)

$69.00$259.00

Reactivity: Human,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CALHM1 antibody (A7858)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CALHM1 antibody.

Alternative names:

Check alternative names for the antibody

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FAM26C antibody
CAHM1_HUMAN antibody|Calcium homeostasis modulator 1 antibody|Calcium homeostasis modulator protein 1 antibody|CALHM1 antibody|FAM26C antibody|Family with sequence similarity 26, member C antibody|MGC39514 antibody|MGC39617 antibody|OTTHUMP00000020413 antibody|Protein FAM26C antibody|Anti-CALHM1 antibody (ab106561)

SCBT cat No:

Name

Rabbit polyclonal CALHM1 antibody

Catalogue No.

A7858

Reactivity

Human, Rat

Immunogen

Recombinant protein of human CALHM1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 38kDa/Observed: Refer to figures

Formulation

CALHM1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CALHM1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FAM26C antibody

Database links

Human UniProt/Swiss-Prot:Q8IU99

Protein names

FAM26C

Protein function

Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner.

Protein tissue specificity

Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells.

Protein sequence and domain

Belongs to the FAM26 family.

Protein cellular localization

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: Colocalizes with HSPA5 at the endoplasmic reticulum.

Background

This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer’s disease in some populations, but the pathogenicity of this polymorphism is unclear.

Note

AntibodyPlus can customize CALHM1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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