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Rabbit polyclonal CALHM1 antibody (A7858)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal CALHM1 antibody.
Check alternative names for the antibodyExpand
CAHM1_HUMAN antibody|Calcium homeostasis modulator 1 antibody|Calcium homeostasis modulator protein 1 antibody|CALHM1 antibody|FAM26C antibody|Family with sequence similarity 26, member C antibody|MGC39514 antibody|MGC39617 antibody|OTTHUMP00000020413 antibody|Protein FAM26C antibody|Anti-CALHM1 antibody (ab106561)
SCBT cat No:
Rabbit polyclonal CALHM1 antibody
|Catalogue No.|| |
Recombinant protein of human CALHM1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 38kDa/Observed: Refer to figures
CALHM1 antibody was tube-contained.
CALHM1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner.
|Protein tissue specificity|| |
Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells.
|Protein sequence and domain|| |
Belongs to the FAM26 family.
|Protein cellular localization|| |
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: Colocalizes with HSPA5 at the endoplasmic reticulum.
This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer’s disease in some populations, but the pathogenicity of this polymorphism is unclear.
AntibodyPlus can customize CALHM1 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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