Rabbit polyclonal CALR antibody (A1066)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,ICC,IF,IP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CALR antibody (A1066)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,ICC,IF,IP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 ICC 1:20 – 1:100 IF 1:20 – 1:100 IP 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CALR antibody.

Alternative names:

Check alternative names for the antibody

Expand

CALR antibody,CRT antibody,FLJ26680 antibody,RO antibody,SSA antibody,cC1qR antibody
Autoantigen RO antibody|CALR antibody|CALR protein antibody|CALR_HUMAN antibody|Calregulin antibody|Calreticulin antibody|cC1qR antibody|CRP55 antibody|CRT antibody|CRTC antibody|Endoplasmic reticulum resident protein 60 antibody|Epididymis secretory sperm binding protein Li 99n antibody|ERp60 antibody|FLJ26680 antibody|grp60 antibody|HACBP antibody|HEL S 99n antibody|RO antibody|Sicca syndrome antigen A (autoantigen Ro; calreticulin) antibody|Sicca syndrome antigen A antibody|SSA antibody|Anti-Calreticulin antibody (ab2907)

SCBT cat No: sc-101436|sc-166837|sc-6467|sc-373863|sc-166839|sc-11398|sc-6468|sc-7431|

Name

Rabbit polyclonal CALR antibody

Catalogue No.

A1066

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CALR

Host

Rabbit

Applications

WB, IHC, ICC, IF, IP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
ICC 1:20 – 1:100
IF 1:20 – 1:100
IP 1:20 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 60kDa/Observed: Refer to Figures

Formulation

CALR antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CALR antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CALR antibody,CRT antibody,FLJ26680 antibody,RO antibody,SSA antibody,cC1qR antibody

Database links

Human UniProt/Swiss-Prot:P27797

Protein names

CALR,CRT,FLJ26680,RO,SSA,cC1qR

Protein function

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).

Protein sequence and domain

Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.; The interaction with glycans occurs through a binding site in the globular lectin domain.; The zinc binding sites are localized to the N-domain.; Associates with PDIA3 through the tip of the extended arm formed by the P-domain.Belongs to the calreticulin family.

Protein cellular localization

Endoplasmic reticulum lumen . Cytoplasm, cytosol . Secreted, extracellular space, extracellular matrix . Cell surface . Sarcoplasmic reticulum lumen . Note: Also found in cell surface (T cells), cytosol and extracellular matrix . Associated with the lytic granules in the cytolytic T-lymphocytes.

Background

Calcium is a universal signaling molecule involved in many cellular functions such as cell motility, metabolism, protein modification, protein folding and apoptosis. Calcium is stored in the endoplasmic reticulum (ER), where it is buffered by calcium binding chaperones such as calnexin and calreticulin, and is released via the IP3 Receptor (1). Calreticulin also functions as an ER chaperone that ensures proper folding and quality control of newly synthesized glycoproteins. As such, calreticulin presumably does not alter protein folding but ensures proper timing for efficient folding and subunit assembly. Furthermore, calreticulin retains proteins in non-native conformation within the ER and targets them for degradation (2,3).

Research area

All research areas>Transport and Trafficking>Calregulin
(View all antibody categories related to Transport and Trafficking)

Note

AntibodyPlus can customize CALR antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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