Rabbit polyclonal CAMK4 antibody (A5304)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CAMK4 antibody (A5304)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CAMK4 antibody.

Alternative names:

Check alternative names for the antibody

Expand

IV antibody, caMK antibody, CaMK IV antibody, CaMK-GR antibody
Brain Ca(2+) calmodulin dependent protein kinase type 4 antibody|Brain Ca(2+) calmodulin dependent protein kinase type IV antibody|Brain Ca++-calmodulin dependent protein kinase type IV antibody|Calcium / calmodulin dependent protein kinase type 4 catalytic chain antibody|Calcium / calmodulin dependent protein kinase type IV catalytic chain antibody|Calcium/calmodulin dependent protein kinase IV antibody|Calcium/calmodulin dependent protein kinase type IV antibody|Calcium/calmodulin-dependent protein kinase type IV antibody|CAM kinase 4 antibody|CAM kinase GR antibody|CAM kinase IV antibody|CAM kinase-GR antibody|CaMK 4 antibody|CAMK GR antibody|CaMK IV antibody|Camk4 antibody|CaMKGR antibody|IV antibody|KCC4_HUMAN antibody|MGC36771 antibody|Anti-CAMKIV antibody (ab3557)

SCBT cat No: sc-136249|sc-166156|sc-166157|sc-1545|sc-17762|sc-9036|sc-55501|

Name

Rabbit polyclonal CAMK4 antibody

Catalogue No.

A5304

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CAMK4

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 52kDa/Observed: Refer to Figures

Formulation

CAMK4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CAMK4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

IV antibody, caMK antibody, CaMK IV antibody, CaMK-GR antibody

Database links

Human UniProt/Swiss-Prot:Q16566

Protein names

IV, caMK, CaMK IV, CaMK-GR

Protein function

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on ‘Ser-133’ in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

Protein tissue specificity

Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.

Protein sequence and domain

The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.; Contains 1 protein kinase domain.

Protein post-translational modifications

Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13.; Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation.

Protein cellular localization

Cytoplasm. Nucleus. Note: Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity).

Background

The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.

Research area

All research areas>Kinases and Phosphatases>CaMK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize CAMK4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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