Rabbit polyclonal CAPN1 antibody (A1172)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CAPN1 antibody (A1172)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CAPN1 antibody.

Alternative names:

Check alternative names for the antibody

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CAPN1 antibody,CANP antibody,CANP1 antibody,CANPL1 antibody,muCANP antibody,muCL antibody
Ca2 activated neutral protease antibody|Calcium activated neutral proteinase antibody|Calcium activated neutral proteinase small subunit antibody|Calcium dependent protease small subunit 1 antibody|Calcium dependent protease small subunit antibody|Calcium-activated neutral proteinase 1 antibody|Calpain 1 antibody|Calpain 1 large subunit antibody|Calpain 1, (mu/I) large subunit antibody|Calpain mu type antibody|Calpain mu-type antibody|Calpain regulatory subunit antibody|Calpain small subunit 1 antibody|Calpain, large polypeptide L1 antibody|Calpain-1 catalytic subunit antibody|Calpain-1 large subunit antibody|CAN1_HUMAN antibody|CANP 1 antibody|CANP antibody|CANP small subunit antibody|CANP1 antibody|CANPL 1 antibody|CANPL1 antibody|CAPN 1 antibody|CAPN1 antibody|Cell proliferation inducing protein 30 antibody|Cell proliferation-inducing gene 30 protein antibody|Micromolar Calpain antibody|Micromolar-calpain antibody|Mu Calpain antibody|muCANP antibody|muCL antibody|Anti-Calpain 1 antibody [EPR3319] (ab108400)

SCBT cat No: sc-32796|sc-32327|sc-390677|sc-7530|sc-271313|sc-13990|sc-7531|sc-81171|sc-58326|

Name

Rabbit polyclonal CAPN1 antibody

Catalogue No.

A1172

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CAPN1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 82kDa/Observed: Refer to Figures

Formulation

CAPN1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CAPN1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CAPN1 antibody,CANP antibody,CANP1 antibody,CANPL1 antibody,muCANP antibody,muCL antibody

Database links

Human UniProt/Swiss-Prot:P07384

Protein names

CAPN1,CANP,CANP1,CANPL1,muCANP,muCL

Protein function

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

Belongs to the peptidase C2 family.; Contains 1 calpain catalytic domain.; Contains 4 EF-hand domains.

Protein post-translational modifications

Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms.

Protein cellular localization

Cytoplasm . Cell membrane . Note: Translocates to the plasma membrane upon Ca(2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 .

Background

Calpain is a calcium-dependent thiol proteinase that is functionally active as a heterodimer composed of a small regulatory subunit and one of at least two large catalytic subunits (calpain 1 or calpain 2). In vitro, calpain 1 (mu-calpain) requires micromolar levels of calcium, while calpain 2 (M-calpain) requires millimolar levels of calcium for activation. The regulation of calpain in vivo is the subject of many current studies, which suggest that proteolytic activity is regulated post-transcriptionally by mechanisms such as calcium requirements, subcellular localization of the heterodimer, phosphorylation via the EGFR-Erk signaling cascade, endogenous inhibitors (calpastatin) and autoproteolytic cleavage (1). Calpastatin negatively regulates autoproteolytic cleavage of calpain 1 between Gly27 and Leu28 (2). Calpain influences cell migration by modifying rather than degrading its substrates responsible for cell adhesion and cytoskeletal arrangement. Control of calpain activity has caught the attention of drug development since limiting its activity could mute invasiveness of tumors or chronic inflammation (1).

Research area

All research areas>Synthesis and Degradation>Calpain
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize CAPN1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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