Rabbit polyclonal CAPNS1 antibody (A6539)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CAPNS1 antibody (A6539)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CAPNS1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

30K antibody, CANP antibody, CDPS antibody, CSS1 antibody, CANPS antibody, CAPN4 antibody, CALPAIN4 antibody
30K antibody|Calcium activated neutral proteinase antibody|Calcium activated neutral proteinase small subunit antibody|Calcium dependent protease small subunit 1 antibody|Calcium dependent protease small subunit antibody|Calcium-activated neutral proteinase small subunit antibody|Calcium-dependent protease small subunit 1 antibody|Calcium-dependent protease small subunit antibody|Calpain 4 antibody|Calpain 4 small subunit (30K) antibody|Calpain 4 small subunit antibody|Calpain regulatory subunit antibody|Calpain small polypeptide antibody|Calpain small subunit 1 antibody|Calpain4 antibody|CalpainS1 antibody|CANP antibody|CANP small subunit antibody|CANPS antibody|CAPN 4 antibody|CAPN S1 antibody|CAPN4 antibody|CAPNS 1 antibody|CAPNS antibody|Capns1 antibody|CDPS antibody|CPNS1_HUMAN antibody|CSS 1 antibody|CSS1 antibody|Anti-Calpain S1 antibody [EPR3324] (ab92333)

SCBT cat No: sc-32785|sc-7528|sc-30065|sc-32325|

Name

Rabbit polyclonal CAPNS1 antibody

Catalogue No.

A6539

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CAPNS1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 28kDa/Observed: Refer to figures

Formulation

CAPNS1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CAPNS1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

30K antibody, CANP antibody, CDPS antibody, CSS1 antibody, CANPS antibody, CAPN4 antibody, CALPAIN4 antibody

Database links

Human UniProt/Swiss-Prot:P04632

Protein names

30K, CANP, CDPS, CSS1, CANPS, CAPN4, CALPAIN4

Protein function

Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Protein sequence and domain

The contact of the 5th EF-hand domain from each monomer allows the formation of the homodimer and also appears to mediate the contact between the large catalytic subunit and small regulatory subunit for the formation of the heterodimer.; EF-hand domains are paired. EF-hand 1 is paired with EF-hand 2 and EF-hand 3 is paired with EF-hand 4. The fifth EF-hand domain, left unpaired, does not bind the calcium but is responsible of the dimerization by EF-embrace. The first four EF-hand domains bind calcium, however it is not sure if the binding of EF-hand 4 to calcium is physiologically relevant.Contains 5 EF-hand domains.

Protein cellular localization

Cytoplasm . Cell membrane . Note: Translocates to the plasma membrane upon calcium binding.

Background

Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene.

Research area

All research areas>Synthesis and Degradation>Calpain
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize CAPNS1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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