Rabbit polyclonal CARD11 antibody (A7140)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CARD11 antibody (A7140)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CARD11 antibody.

Alternative names:

Check alternative names for the antibody

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PPBL antibody, BENTA antibody, BIMP3 antibody, IMD11 antibody, CARMA1 antibody
0610008L17Rik antibody|2410011D02Rik antibody|Bcl10 interacting maguk protein 3 antibody|BIMP 3 antibody|BIMP3 antibody|CAR11_HUMAN antibody|CARD 11 antibody|CARD containing MAGUK protein 3 antibody|Card maguk protein 1 antibody|CARD-containing MAGUK protein 1 antibody|CARD11 antibody|CARD11 protein antibody|Carma 1 antibody|CARMA1 antibody|Caspase recruitment domain containing protein 11 antibody|Caspase recruitment domain family member 11 antibody|Caspase recruitment domain-containing protein 11 antibody|MGC133069 antibody|Anti-CARD11 antibody – C-terminal (ab189167)

SCBT cat No: sc-166910|sc-48737|sc-20458|

Name

Rabbit polyclonal CARD11 antibody

Catalogue No.

A7140

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human CARD11

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 133kDa/Observed: Refer to figures

Formulation

CARD11 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CARD11 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PPBL antibody, BENTA antibody, BIMP3 antibody, IMD11 antibody, CARMA1 antibody

Database links

Human UniProt/Swiss-Prot:Q9BXL7

Protein names

PPBL, BENTA, BIMP3, IMD11, CARMA1

Protein function

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.

Protein tissue specificity

Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt’s lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells.

Protein sequence and domain

Contains 1 CARD domain.; Contains 1 guanylate kinase-like domain.; Contains 1 PDZ (DHR) domain.

Protein post-translational modifications

Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.

Protein cellular localization

Cytoplasm . Membrane raft . Note: Colocalized with DPP4 in membrane rafts.

Background

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.

Research area

All research areas>Neurobiology>CARD
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize CARD11 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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