Rabbit polyclonal CASP1 antibody (A0964)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CASP1 antibody (A0964)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

CASP1 antibody,ICE antibody,IL1BC antibody,P45 antibody, Caspase-1 antibody
CASP-1 antibody|CASP1 antibody|CASP1_HUMAN antibody|Caspase 1 antibody|Caspase-1 subunit p10 antibody|ICE antibody|IL-1 beta-converting enzyme antibody|IL-1BC antibody|IL1 beta converting enzyme antibody|IL1B convertase antibody|Interleukin 1 beta convertase antibody|Interleukin 1B converting enzyme antibody|Interleukin-1 beta convertase antibody|Interleukin-1 beta-converting enzyme antibody|p45 antibody|Anti-Caspase-1 antibody

SCBT cat No: sc-514|sc-1780|sc-398715|sc-1597|sc-1218|sc-134299|

Name

Rabbit polyclonal CASP1 antibody

Catalogue No.

A0964

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human CASP1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 45kDa/Observed: Refer to Figures

Formulation

CASP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CASP1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CASP1 antibody,ICE antibody,IL1BC antibody,P45 antibody, Caspase-1 antibody

Database links

Human UniProt/Swiss-Prot:P29466

Protein names

CASP1,ICE,IL1BC,P45, Caspase-1

Protein function

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

Protein tissue specificity

Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.

Protein sequence and domain

Belongs to the peptidase C14A family.; Contains 1 CARD domain.

Protein post-translational modifications

The two subunits are derived from the precursor sequence by an autocatalytic mechanism.

Protein cellular localization

Cytoplasm.

Background

Caspase-1, or interleukin-1ß converting enzyme (ICE/ICEalpha), is a class I cysteine protease, which also includes caspases -4, -5, -11, and -12. Caspase-1 cleaves inflammatory cytokines such as pro-IL-1ß and interferon-gamma inducing factor (IL-18) into their mature forms (1,2). Like other caspases, caspase-1 is proteolytically activated from a proenzyme to produce a tetramer of its two active subunits, p20 and p10. Caspase-1 has a large amino-terminal pro-domain that contains a caspase recruitment domain (CARD). Overexpression of caspase-1 can induce apoptosis (3). Mice deficient in caspase-1, however, have no overt defects in apoptosis but do have defects in the maturation of pro-IL-1beta and are resistant to endotoxic shock (4,5). At least six caspase-1 isoforms have been identified, including caspase-1 alpha, beta, gamma, delta, epsilon and zeta (6). Most caspase-1 isoforms (alpha, beta, gamma and delta) produce products between 30-48 kDa and induce apoptosis upon over-expression. Caspase-1 epsilon typically contains only the p10 subunit, does not induce apoptosis and may act as a dominant negative. The widely expressed zeta isoform of caspase-1 induces apoptosis and lacks 39 amino-terminal residues found in the alpha isoform (6). Activation of caspase-1 occurs through an oligomerization molecular platform designated the “inflammasome” that includes caspase-5, Pycard/Asc, and NALP1 (7).

Research area

All research areas>Tumor Suppressor/Apoptosis>Caspase
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize CASP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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