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Rabbit polyclonal CASP14 antibody (A6541)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal CASP14 antibody.
Check alternative names for the antibodyExpand
CASP-5 antibody|CASP5 antibody|CASP5_HUMAN antibody|Caspase-5 subunit p10 antibody|ICE(rel)-III antibody|ICERELIII antibody|ICH 3 antibody|ICH 3 protease antibody|Protease ICH-3 antibody|Protease TY antibody|TY antibody|TY protease antibody|Anti-Caspase-14 antibody [EPR12927] (ab174847)
SCBT cat No: sc-136351|sc-56040|sc-48395|sc-48336|sc-5628|sc-515259|sc-9644|
Rabbit polyclonal CASP14 antibody
|Catalogue No.|| |
Recombinant protein of human CASP14
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 27kDa/Observed: Refer to figures
CASP14 antibody was tube-contained.
CASP14 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum . Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF . Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function . Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD .
|Protein tissue specificity|| |
Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels . The p17/10 mature form is expressed in epidermis stratum corneum, the p20/p8 intermediate form in epidermis upper granular cells of the stratum granulosum .
|Protein sequence and domain|| |
Belongs to the peptidase C14A family.
|Protein post-translational modifications|| |
Maturation by proteolytic processing appears to be a two-step process. The precursor is processed by KLK7 to yield the p20/p8 intermediate form which acts on the precursor to yield the p17/p10 mature form . Initially, cleavage between Ile-152 and Lys-153 has been proposed to yield the large and small subunits of the active enzyme .
|Protein cellular localization|| |
Cytoplasm . Nucleus .
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
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|Product type|| |
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